TY - JOUR
T1 - The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
AU - Gröschel, Matthias I.
AU - Meehan, Conor J.
AU - Barilar, Ivan
AU - Diricks, Margo
AU - Gonzaga, Aitor
AU - Steglich, Matthias
AU - Conchillo-Solé, Oscar
AU - Scherer, Isabell Christin
AU - Mamat, Uwe
AU - Luz, Christian F.
AU - De Bruyne, Katrien
AU - Utpatel, Christian
AU - Yero, Daniel
AU - Gibert, Isidre
AU - Daura, Xavier
AU - Kampmeier, Stefanie
AU - Rahman, Nurdyana Abdul
AU - Kresken, Michael
AU - van der Werf, Tjip S.
AU - Alio, Ifey
AU - Streit, Wolfgang R.
AU - Zhou, Kai
AU - Schwartz, Thomas
AU - Rossen, John W.A.
AU - Farhat, Maha R.
AU - Schaible, Ulrich E.
AU - Nübel, Ulrich
AU - Rupp, Jan
AU - Steinmann, Joerg
AU - Niemann, Stefan
AU - Kohl, Thomas A.
PY - 2020/4/27
Y1 - 2020/4/27
N2 - Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.
AB - Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.
KW - Alleles
KW - Anti-Bacterial Agents/pharmacology
KW - Cluster Analysis
KW - Cross Infection/microbiology
KW - Drug Resistance, Multiple, Bacterial/genetics
KW - Genome, Bacterial
KW - Geography
KW - Gram-Negative Bacterial Infections/drug therapy
KW - Humans
KW - Opportunistic Infections/microbiology
KW - Phylogeny
KW - Stenotrophomonas maltophilia/drug effects
KW - Virulence
UR - http://www.scopus.com/inward/record.url?scp=85083972595&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-15123-0
DO - 10.1038/s41467-020-15123-0
M3 - Artículo
C2 - 32341346
AN - SCOPUS:85083972595
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 2044
ER -
