TY - JOUR
T1 - The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii
AU - Gaona, Marc
AU - Corral, Jordi
AU - Campoy, Susana
AU - Barbé, Jordi
AU - Pérez−Varela, María
AU - Aranda, Jesús
N1 - Publisher Copyright:
© 2024 American Society for Microbiology.
PY - 2024/8/28
Y1 - 2024/8/28
N2 - Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. baumannii efflux pump SxtP belonging to the MFS superfamily (major facilitator superfamily), along with its associated activator LysR-type transcriptional regulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.
AB - Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. baumannii efflux pump SxtP belonging to the MFS superfamily (major facilitator superfamily), along with its associated activator LysR-type transcriptional regulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.
KW - Acinetobacter
KW - LysR-type transcriptional regulator
KW - MFS efflux pump
KW - co-trimoxazole
KW - Acinetobacter baumannii/genetics
KW - Drug Resistance, Multiple, Bacterial/genetics
KW - Transcription Factors/genetics
KW - Anti-Bacterial Agents/pharmacology
KW - Virulence/genetics
KW - Membrane Transport Proteins/genetics
KW - Trimethoprim, Sulfamethoxazole Drug Combination/pharmacology
KW - Microbial Sensitivity Tests
KW - Animals
KW - Bacterial Proteins/genetics
KW - Mice
KW - Gene Expression Regulation, Bacterial
KW - Acinetobacter Infections/microbiology
UR - https://www.mendeley.com/catalogue/b27df617-a296-3ee4-af68-48af43bffd18/
UR - http://www.scopus.com/inward/record.url?scp=85206018199&partnerID=8YFLogxK
U2 - 10.1128/aac.00712-24
DO - 10.1128/aac.00712-24
M3 - Article
C2 - 39194207
SN - 0066-4804
VL - 68
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 10
M1 - e00712-24
ER -
