The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets

Keyphrases

• Cell Signaling 100%
• Breast Cancer 100%
• Cellular Heterogeneity 100%
• Tumor Heterogeneity 100%
• Signaling Factors 100%
• Real Potential 100%
• Protein Expression 75%
• Oncogenic Alterations 50%
• Classical Studies 25%
• In Cancer 25%
• Tumor 25%
• Cancer Therapy 25%
• Tumor Cells 25%
• Phosphoinositide 3-kinase (PI3K) 25%
• Druggability 25%
• Phosphorylation 25%
• Primary Tumor 25%
• 4E-BP1 25%
• Hypoxia 25%
• Human Tumors 25%
• Local Factors 25%
• Human Epidermal Growth Factor Receptor 2 (HER2) 25%
• Systemic Therapy 25%
• Chemotherapy Resistance 25%
• Tumor Dissemination 25%
• Subclone 25%
• Metastatic Dissemination 25%
• Protein Translation 25%
• Heterogeneous Tumors 25%
• AKT1 25%
• Morphological Level 25%
• Malignant Tumor 25%
• Eukaryotic Translation Initiation Factor 4E (eIF4E) 25%
• P-MAPK 25%
• Tumor Resistance 25%
• Heterogeneous Expression 25%
• Expression Proteomics 25%
• Tissue Heterogeneity 25%

Medicine and Dentistry

• Breast Cancer 100%
• Tumour Heterogeneity 100%
• Signal Transduction 100%
• Protein Expression 75%
• Neoplasm 50%
• Morphology 25%
• Hypoxia 25%
• Cancer Therapy 25%
• Tumor Cell 25%
• Proteomics 25%
• Malignant Neoplasm 25%
• Systemic Therapy 25%
• Primary Tumor 25%
• Tumor Resistance 25%
• Initiation Factor 4E 25%
• Translation (Protein Synthesis) 25%

Biochemistry, Genetics and Molecular Biology

• Signal Transduction 100%
• Protein Expression 66%
• Translation (Protein Synthesis) 33%
• Genetics 33%
• Proteomics 33%
• Morphology 33%
• Protein Expression Level 33%