TY - JOUR
T1 - The impact of bilingualism on brain structure and function in Huntington's disease
AU - Martínez-Horta, Saul
AU - Moreu, Andrea
AU - Perez-Perez, Jesús
AU - Sampedro, Frederic
AU - Horta-Barba, Andrea
AU - Pagonabarraga, Javier
AU - Gomez-Anson, Beatriz
AU - Lozano-Martinez, Gloria Andrea
AU - Lopez-Mora, Diego Alfonso
AU - Camacho, Valle
AU - Fernández-León, Alejandro
AU - Carrió, Ignasi
AU - Kulisevsky, Jaime
PY - 2019/3/1
Y1 - 2019/3/1
N2 - © 2018 Elsevier Ltd Introduction: Bilingualism exerts neuroprotective effects against neurodegeneration. In Huntington's disease (HD), the systems involved in bilingual control show early compromise, but the effect of bilingualism on the course of HD is unknown. Methods: We addressed the impact of livelong use of bilingualism on the clinical features, brain structure and function in 30 early-mild stage HD patients. Using voxel-wise regression analysis, we explored the effect of levels of use of bilingualism on grey-matter volume (GMV) and 18F-FDG metabolism. Results: Higher use of bilingualism was associated with better performance in inhibitory control and set-shifting independently of age and education and with higher GMV in the inferior frontal gyrus. 18F-FDG data revealed a significant effect on multiple fronto-temporal regions, specifically, in the dorsal anterior cingulate cortex, the anterior insula, the ventromedial orbital prefrontal cortex and the inferior frontal gyrus. These changes contributed to better inhibitory control and set-shifting and to more preserved motor and functional capacity. Conclusion: In HD, lifelong use of bilingualism is associated with structural and metabolic brain changes that have an impact on cognition, movement and functionality. These findings highlight the importance of stimulating cognitive and brain reserve in HD and in other neurodegenerative conditions.
AB - © 2018 Elsevier Ltd Introduction: Bilingualism exerts neuroprotective effects against neurodegeneration. In Huntington's disease (HD), the systems involved in bilingual control show early compromise, but the effect of bilingualism on the course of HD is unknown. Methods: We addressed the impact of livelong use of bilingualism on the clinical features, brain structure and function in 30 early-mild stage HD patients. Using voxel-wise regression analysis, we explored the effect of levels of use of bilingualism on grey-matter volume (GMV) and 18F-FDG metabolism. Results: Higher use of bilingualism was associated with better performance in inhibitory control and set-shifting independently of age and education and with higher GMV in the inferior frontal gyrus. 18F-FDG data revealed a significant effect on multiple fronto-temporal regions, specifically, in the dorsal anterior cingulate cortex, the anterior insula, the ventromedial orbital prefrontal cortex and the inferior frontal gyrus. These changes contributed to better inhibitory control and set-shifting and to more preserved motor and functional capacity. Conclusion: In HD, lifelong use of bilingualism is associated with structural and metabolic brain changes that have an impact on cognition, movement and functionality. These findings highlight the importance of stimulating cognitive and brain reserve in HD and in other neurodegenerative conditions.
KW - 18F-FDG
KW - Bilingualism
KW - Cognitive reserve
KW - Huntington's disease
KW - VBM
UR - http://www.mendeley.com/research/impact-bilingualism-brain-structure-function-huntingtons-disease
U2 - 10.1016/j.parkreldis.2018.09.017
DO - 10.1016/j.parkreldis.2018.09.017
M3 - Article
C2 - 30249427
SN - 1353-8020
VL - 60
SP - 92
EP - 97
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -