The genetics of East African populations: A Nilo-Saharan component in the African genetic landscape

Begoña Dobon, Hisham Y. Hassan, Hafid Laayouni, Pierre Luisi, Isis Ricaño-Ponce, Alexandra Zhernakova, Cisca Wijmenga, Hanan Tahir, David Comas, Mihai G. Netea, Jaume Bertranpetit

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

24 Cites (Scopus)

Resum

East Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations living in the Sudanese region of East Africa by analysing nine ethnic groups belonging to three African linguistic families: Niger-Kordofanian, Nilo-Saharan and Afro-Asiatic. A total of 500 individuals were genotyped for 200,000 single-nucleotide polymorphisms. Principal component analysis, clustering analysis using ADMIXTURE, F ST statistics, and the three-population test were used to investigate the underlying genetic structure and ancestry of the different ethno-linguistic groups. Our analyses revealed a genetic component for Sudanese Nilo-Saharan speaking groups (Darfurians and part of Nuba populations) related to Nilotes of South Sudan, but not to other Sudanese populations or other sub-Saharan populations. Populations inhabiting the North of the region showed close genetic affinities with North Africa, with a component that could be remnant of North Africans before the migrations of Arabs from Arabia. In addition, we found very low genetic distances between populations in genes important for anti-malarial and anti-bacterial host defence, suggesting similar selective pressures on these genes and stressing the importance of considering functional pathways to understand the evolutionary history of populations.
Idioma originalEnglish
Número d’article9996
RevistaSCIENTIFIC REPORTS
Volum5
DOIs
Estat de la publicacióPublicada - 28 de maig 2015

Fingerprint

Navegar pels temes de recerca de 'The genetics of East African populations: A Nilo-Saharan component in the African genetic landscape'. Junts formen un fingerprint únic.

Com citar-ho