TY - JOUR
T1 - The endogenous opioid system
T2 - A common substrate in drug addiction
AU - Trigo, José Manuel
AU - Martin-García, Elena
AU - Berrendero, Fernando
AU - Robledo, Patricia
AU - Maldonado, Rafael
N1 - Funding Information:
This work was supported by the Spanish “Ministerio de Ciencia e Innovación” (#SAF2007-64062) and “Instituto de Salud Carlos III” (#RD06/001/001 to R.M., PI070709 to P.R., PI070559 to F.B.), the Catalan Government (SGR2009-00131), the ICREA Foundation (ICREA Academia-2008) and the DG Research of the European Commission (NEWMOOD LSHM-CT-2004-503474; GENADDICT, #LSHM-CT-2004-05166; and PHECOMP, #LSHM-CT-2007-037669). Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III, Catalan Government, ICREA Foundation or DG Research of the European Commission had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
PY - 2010/5
Y1 - 2010/5
N2 - Drug addiction is a chronic brain disorder leading to complex adaptive changes within the brain reward circuits that involve several neurotransmitters. One of the neurochemical systems that plays a pivotal role in different aspects of addiction is the endogenous opioid system (EOS). Opioid receptors and endogenous opioid peptides are largely distributed in the mesolimbic system and modulate dopaminergic activity within these reward circuits. Chronic exposure to the different prototypical drugs of abuse, including opioids, alcohol, nicotine, psychostimulants and cannabinoids has been reported to produce significant alterations within the EOS, which seem to play an important role in the development of the addictive process. In this review, we will describe the adaptive changes produced by different drugs of abuse on the EOS, and the current knowledge about the contribution of each component of this neurobiological system to their addictive properties.
AB - Drug addiction is a chronic brain disorder leading to complex adaptive changes within the brain reward circuits that involve several neurotransmitters. One of the neurochemical systems that plays a pivotal role in different aspects of addiction is the endogenous opioid system (EOS). Opioid receptors and endogenous opioid peptides are largely distributed in the mesolimbic system and modulate dopaminergic activity within these reward circuits. Chronic exposure to the different prototypical drugs of abuse, including opioids, alcohol, nicotine, psychostimulants and cannabinoids has been reported to produce significant alterations within the EOS, which seem to play an important role in the development of the addictive process. In this review, we will describe the adaptive changes produced by different drugs of abuse on the EOS, and the current knowledge about the contribution of each component of this neurobiological system to their addictive properties.
KW - Alcohol
KW - Cannabinoids
KW - Dependence
KW - Nicotine
KW - Psychostimulants
KW - Reward
UR - http://www.scopus.com/inward/record.url?scp=77952424429&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2009.10.011
DO - 10.1016/j.drugalcdep.2009.10.011
M3 - Review article
C2 - 19945803
AN - SCOPUS:77952424429
SN - 0376-8716
VL - 108
SP - 183
EP - 194
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
IS - 3
ER -
