Task-Induced deactivation from rest extends beyond the default mode brain network

Ben J. Harrison, Jesus Pujol, Oren Contreras-Rodríguez, Carles Soriano-Mas, Marina López-Solà, Joan Deus, Hector Ortiz, Laura Blanco-Hinojo, Pino Alonso, Rosa Hernández-Ribas, Narcís Cardoner, José M. Menchón

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

72 Cites (Scopus)

Resum

Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes. © 2011 Harrison et al.
Idioma originalEnglish
Número d’articlee22964
RevistaPLoS ONE
Volum6
DOIs
Estat de la publicacióPublicada - 3 d’ag. 2011

Fingerprint

Navegar pels temes de recerca de 'Task-Induced deactivation from rest extends beyond the default mode brain network'. Junts formen un fingerprint únic.

Com citar-ho