TY - JOUR
T1 - Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury
AU - Scarabelli, Tiziano M.
AU - Mariotto, Sofia
AU - Abdel-Azeim, Safwat
AU - Shoji, Kazuo
AU - Darra, Elena
AU - Stephanou, Anastasis
AU - Chen-Scarabelli, Carol
AU - Marechal, Jean Didier
AU - Knight, Richard
AU - Ciampa, Anna
AU - Saravolatz, Louis
AU - de Prati, Alessandra Carcereri
AU - Yuan, Zhaokan
AU - Cavalieri, Elisabetta
AU - Menegazzi, Marta
AU - Latchman, David
AU - Pizza, Cosimo
AU - Perahia, David
AU - Suzuki, Hisanori
PY - 2009/2/4
Y1 - 2009/2/4
N2 - Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity. © 2008 Federation of European Biochemical Societies.
AB - Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity. © 2008 Federation of European Biochemical Societies.
KW - Antioxidant flavonoid
KW - Apoptosis
KW - Heart ischemia/reperfusion
KW - STAT1
KW - Surface plasmon resonance
U2 - 10.1016/j.febslet.2008.12.037
DO - 10.1016/j.febslet.2008.12.037
M3 - Article
SN - 0014-5793
VL - 583
SP - 531
EP - 541
JO - FEBS Letters
JF - FEBS Letters
IS - 3
ER -
