Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies

Mireia Pesarrodona; Toni Jauset; Zamira V. Díaz-Riascos; Alejandro Sánchez-Chardi; Marie Eve Beaulieu; Joaquin Seras-Franzoso; Laura Sánchez-García; Ricardo Baltà-Foix; Sandra Mancilla; Yolanda Fernández; Ursula Rinas; Simó Schwartz; Laura Soucek; Antonio Villaverde; Ibane Abasolo; Esther Vázquez

doi:10.1002/advs.201900849

Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies

Mireia Pesarrodona, Toni Jauset, Zamira V. Díaz-Riascos, Alejandro Sánchez-Chardi, Marie Eve Beaulieu, Joaquin Seras-Franzoso, Laura Sánchez-García, Ricardo Baltà-Foix, Sandra Mancilla, Yolanda Fernández, Ursula Rinas, Simó Schwartz, Laura Soucek, Antonio Villaverde, Ibane Abasolo, Esther Vázquez

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© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44-targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44+ tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic proteins.

Idioma original	English
Número d’article	1900849
Pàgines (de-a)	1900849
Nombre de pàgines	9
Revista	Advanced Science
Volum	6
Número	18
DOIs	https://doi.org/10.1002/advs.201900849
Estat de la publicació	Publicada - 18 de set. 2019

SDG de les Nacions Unides

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10.1002/advs.201900849

https://ddd.uab.cat/record/223366

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http://www.mendeley.com/research/targeting-antitumoral-proteins-breast-cancer-local-administration-functional-inclusion-bodies

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Pesarrodona, M., Jauset, T., Díaz-Riascos, Z. V., Sánchez-Chardi, A., Beaulieu, M. E., Seras-Franzoso, J., Sánchez-García, L., Baltà-Foix, R., Mancilla, S., Fernández, Y., Rinas, U., Schwartz, S., Soucek, L., Villaverde, A., Abasolo, I., & Vázquez, E. (2019). Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies. Advanced Science, 6(18), 1900849. Article 1900849. https://doi.org/10.1002/advs.201900849

@article{a1f0014f3ffe48d1acfb00505475cbf5,

title = "Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies",

abstract = "{\textcopyright} 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44-targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44+ tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic proteins.",

keywords = "biofabrication, cancer therapy, functional amyloids, inclusion bodies, protein drug release, APOPTOSIS, CELLS, ANTIPROLIFERATIVE ACTIVITY, METASTASIS, P21(WAF1/CIP1), HYALURONAN, BACTERIAL AMYLOIDS, INHIBITION, TUMOR-GROWTH, CD44",

author = "Mireia Pesarrodona and Toni Jauset and D{\'i}az-Riascos, {Zamira V.} and Alejandro S{\'a}nchez-Chardi and Beaulieu, {Marie Eve} and Joaquin Seras-Franzoso and Laura S{\'a}nchez-Garc{\'i}a and Ricardo Balt{\`a}-Foix and Sandra Mancilla and Yolanda Fern{\'a}ndez and Ursula Rinas and Sim{\'o} Schwartz and Laura Soucek and Antonio Villaverde and Ibane Abasolo and Esther V{\'a}zquez",

year = "2019",

month = sep,

day = "18",

doi = "10.1002/advs.201900849",

language = "English",

volume = "6",

pages = "1900849",

journal = "Advanced Science",

issn = "2198-3844",

number = "18",

}

Pesarrodona, M, Jauset, T, Díaz-Riascos, ZV, Sánchez-Chardi, A, Beaulieu, ME, Seras-Franzoso, J, Sánchez-García, L, Baltà-Foix, R, Mancilla, S, Fernández, Y, Rinas, U, Schwartz, S, Soucek, L , Villaverde, A, Abasolo, I & Vázquez, E 2019, 'Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies', Advanced Science, vol. 6, núm. 18, 1900849, pàg. 1900849. https://doi.org/10.1002/advs.201900849

TY - JOUR

T1 - Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies

AU - Pesarrodona, Mireia

AU - Jauset, Toni

AU - Díaz-Riascos, Zamira V.

AU - Sánchez-Chardi, Alejandro

AU - Beaulieu, Marie Eve

AU - Seras-Franzoso, Joaquin

AU - Sánchez-García, Laura

AU - Baltà-Foix, Ricardo

AU - Mancilla, Sandra

AU - Fernández, Yolanda

AU - Rinas, Ursula

AU - Schwartz, Simó

AU - Soucek, Laura

AU - Villaverde, Antonio

AU - Abasolo, Ibane

AU - Vázquez, Esther

PY - 2019/9/18

Y1 - 2019/9/18

N2 - © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44-targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44+ tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic proteins.

AB - © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44-targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44+ tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic proteins.

KW - biofabrication

KW - cancer therapy

KW - functional amyloids

KW - inclusion bodies

KW - protein drug release

KW - APOPTOSIS

KW - CELLS

KW - ANTIPROLIFERATIVE ACTIVITY

KW - METASTASIS

KW - P21(WAF1/CIP1)

KW - HYALURONAN

KW - BACTERIAL AMYLOIDS

KW - INHIBITION

KW - TUMOR-GROWTH

KW - CD44

UR - http://www.mendeley.com/research/targeting-antitumoral-proteins-breast-cancer-local-administration-functional-inclusion-bodies

U2 - 10.1002/advs.201900849

DO - 10.1002/advs.201900849

M3 - Article

C2 - 31559131

SN - 2198-3844

VL - 6

SP - 1900849

JO - Advanced Science

JF - Advanced Science

IS - 18

M1 - 1900849

ER -

Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies

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