T-maze performance in rats following chronic neuroleptic treatment

Sergi Ferré; Gemma Prat; Teresa Guix; Montserrat Gomá; Francesc Jané; Miquel Casas

doi:10.1016/0091-3057(90)90190-S

T-maze performance in rats following chronic neuroleptic treatment

Sergi Ferré, Gemma Prat, Teresa Guix, Montserrat Gomá, Francesc Jané, Miquel Casas

Departament de Psiquiatria i Medicina Legal

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The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decreased of dopaminergic neurotransmission. © 1990.

Idioma original	Anglès
Pàgines (de-a)	481-484
Revista	Pharmacology Biochemistry and Behavior
Volum	35
DOIs	https://doi.org/10.1016/0091-3057(90)90190-S
Estat de la publicació	Publicada - 1 de gen. 1990

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10.1016/0091-3057(90)90190-S

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@article{3c01e24c33c34e6eb26a0fc868767f83,

title = "T-maze performance in rats following chronic neuroleptic treatment",

abstract = "The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decreased of dopaminergic neurotransmission. {\textcopyright} 1990.",

keywords = "Chronic treatment, Food-reinforced behaviour, Haloperidol, Locomotor activity, rat",

author = "Sergi Ferr{\'e} and Gemma Prat and Teresa Guix and Montserrat Gom{\'a} and Francesc Jan{\'e} and Miquel Casas",

year = "1990",

month = jan,

day = "1",

doi = "10.1016/0091-3057(90)90190-S",

language = "English",

volume = "35",

pages = "481--484",

journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier",

}

TY - JOUR

T1 - T-maze performance in rats following chronic neuroleptic treatment

AU - Ferré, Sergi

AU - Prat, Gemma

AU - Guix, Teresa

AU - Gomá, Montserrat

AU - Jané, Francesc

AU - Casas, Miquel

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decreased of dopaminergic neurotransmission. © 1990.

AB - The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decreased of dopaminergic neurotransmission. © 1990.

KW - Chronic treatment

KW - Food-reinforced behaviour

KW - Haloperidol

KW - Locomotor activity

KW - rat

U2 - 10.1016/0091-3057(90)90190-S

DO - 10.1016/0091-3057(90)90190-S

M3 - Article

SN - 0091-3057

VL - 35

SP - 481

EP - 484

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

ER -

T-maze performance in rats following chronic neuroleptic treatment

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