TY - CHAP
T1 - Systems Biology of Monovalent Cation Homeostasis in Yeast. The Translucent Contribution.
AU - Ariño, Joaquín
AU - Aydar, Ebru
AU - Drulhe, Samuel
AU - Ganser, Daniel
AU - Jorrín, Jesús
AU - Kahm, Matthias
AU - Krause, Falko
AU - Petrezsélyová, Silvia
AU - Yenush, Lynne
AU - Zimmermannová, Olga
AU - Van Heusden, G. Paul H.
AU - Kschischo, Maik
AU - Ludwig, Jost
AU - Palmer, Chris
AU - Ramos, José
AU - Sychrová, Hana
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Maintenance of monovalent cation homeostasis (mainly K+ and Na+) is vital for cell survival, and cation toxicity is at the basis of a myriad of relevant phenomena, such as salt stress in crops and diverse human diseases. Full understanding of the importance of monovalent cations in the biology of the cell can only be achieved from a systemic perspective. Translucent is a multinational project developed within the context of the SysMO (System Biology of Microorganisms) initiative and focussed in the study of cation homeostasis using the well-known yeast Saccharomyces cerevisiae as a model. The present review summarize how the combination of biochemical, genetic, genomic and computational approaches has boosted our knowledge in this field, providing the basis for a more comprehensive and coherent vision of the role of monovalent cations in the biology of the cell. © 2014 Elsevier Ltd.
AB - Maintenance of monovalent cation homeostasis (mainly K+ and Na+) is vital for cell survival, and cation toxicity is at the basis of a myriad of relevant phenomena, such as salt stress in crops and diverse human diseases. Full understanding of the importance of monovalent cations in the biology of the cell can only be achieved from a systemic perspective. Translucent is a multinational project developed within the context of the SysMO (System Biology of Microorganisms) initiative and focussed in the study of cation homeostasis using the well-known yeast Saccharomyces cerevisiae as a model. The present review summarize how the combination of biochemical, genetic, genomic and computational approaches has boosted our knowledge in this field, providing the basis for a more comprehensive and coherent vision of the role of monovalent cations in the biology of the cell. © 2014 Elsevier Ltd.
KW - Cation transport
KW - Potassium homeostasis
KW - Saccharomyces cerevisiae
KW - Salt stress
KW - Systems biology
U2 - 10.1016/B978-0-12-800143-1.00001-4
DO - 10.1016/B978-0-12-800143-1.00001-4
M3 - Chapter
SN - 0065-2911
VL - 64
SP - 1
EP - 63
BT - Advances in Microbial Physiology
ER -
