Systemic Coronavirus-associated disease in the domestic ferret (Mustela putorius): Histopathologic and immunohistochemical characterization in three ferrets

C. Laprie, J. Duboy, J. Martinez

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Resum

Background: A disease resembling feline infectious peritonitis (FIP) has been recognized recently in ferrets, mostly in United States and in Spain. This disease is due to a Group 1 Coronavirus, closely related to the ferret enteric Coronavirus. Objective: To demonstrate the viral origin of severe pyogranulomatous lymphoid and visceral lesions in three ferrets. Methods: Histopathology and immunohistochemistry of lesions received in our laboratory. Results: Severe pyogranulomatous inflammation was observed in the abdominal lymph nodes and in various organs. Positive labelling of Coronavirus antigen was demonstrated in macrophages in the pyogranulomatous lesions by immunohistochemistry. Conclusion: The three cases of severe pyogranulomatous disseminated inflammation were due to a Coronavirus, causing a systemic coronavirosis in ferret with a high similarity to FIP. © 2009 AFVAC.
Idioma originalEnglish
Pàgines (de-a)111-115
RevistaPratique Medicale et Chirurgicale de l'Animal de Compagnie
Volum44
Número4
DOIs
Estat de la publicacióPublicada - 1 d’oct. 2009

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