TY - JOUR
T1 - Synthesis and activity studies in vitro and in vivo of a new series of malonato-platinum(II) complexes containing sulfide and phosphine ligands
AU - Sampedro, F.
AU - Molins-Pujol, AM
AU - Ruiz, JI
AU - Santaló, P.
AU - Bonal, J.
AU - Pueyo, M.
AU - Llagostera, M.
AU - Sánchez-Ferrando, F.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Three new malonato platinum(II) complexes containing P and S ligands are reported. In in vitro tests, all three compounds showed damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using leukemia L1210° cells on mice BDF, show that two of these compounds are potentially active. © 1992.
AB - Three new malonato platinum(II) complexes containing P and S ligands are reported. In in vitro tests, all three compounds showed damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using leukemia L1210° cells on mice BDF, show that two of these compounds are potentially active. © 1992.
KW - antitumoral activity
KW - cancer treatment
KW - L1210° leukemia
KW - malonate
KW - platinum(II)-complex
KW - platinum(II)-DNA damage
U2 - 10.1016/0223-5234(92)90139-R
DO - 10.1016/0223-5234(92)90139-R
M3 - Article
SN - 0223-5234
VL - 27
SP - 611
EP - 614
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 6
ER -
