Study of allelic losses on 3p, 6q, and 17p in human urothelial cancer

Marta Bernués; Carme Casadevall; M. Rosa Caballín; Rosa Miró; M. José Ejarque; Gilberto Chéchile; Antoni Gelabert; José Egozcue

doi:10.1016/S0165-4608(98)00248-9

Study of allelic losses on 3p, 6q, and 17p in human urothelial cancer

Marta Bernués, Carme Casadevall, M. Rosa Caballín, Rosa Miró, M. José Ejarque, Gilberto Chéchile, Antoni Gelabert, José Egozcue

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

15 Cites (Scopus)

Resum

Forty-eight transitional cell carcinomas of the bladder and three transitional cell carcinomas of the renal pelvis were examined for loss of heterozygosity (LOH) on chromosomes 3p, 6q, and 17p. The most frequent allelic loss was seen on 17p (18/36, 50%) followed by 6q (6/22, 27%), and 3p (5/22, 23%). In cases with LOH at more than one locus, the same DNA sample often varied in degree of signal reduction for missing alleles. This observation indicates that LOH studies can serve to detect intratumor heterogeneity. No correlation was found between allelic losses at these chromosome arms and tumor grade and stage. Allelic losses on 6q were associated with tumors having a solid growth pattern; in this kind of tumors, allelic losses on 3p were associated with invasion. Copyright (C) 1999 Elsevier Science Inc.

Idioma original	Anglès
Pàgines (de-a)	42-45
Revista	Cancer Genetics and Cytogenetics
Volum	112
Número	1
DOIs	https://doi.org/10.1016/S0165-4608(98)00248-9
Estat de la publicació	Publicada - 1 de jul. 1999

SDG de les Nacions Unides

Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

Accés al document

10.1016/S0165-4608(98)00248-9

Com citar-ho

@article{9bf80f397b9445568f8984131f6fe9cd,

title = "Study of allelic losses on 3p, 6q, and 17p in human urothelial cancer",

abstract = "Forty-eight transitional cell carcinomas of the bladder and three transitional cell carcinomas of the renal pelvis were examined for loss of heterozygosity (LOH) on chromosomes 3p, 6q, and 17p. The most frequent allelic loss was seen on 17p (18/36, 50%) followed by 6q (6/22, 27%), and 3p (5/22, 23%). In cases with LOH at more than one locus, the same DNA sample often varied in degree of signal reduction for missing alleles. This observation indicates that LOH studies can serve to detect intratumor heterogeneity. No correlation was found between allelic losses at these chromosome arms and tumor grade and stage. Allelic losses on 6q were associated with tumors having a solid growth pattern; in this kind of tumors, allelic losses on 3p were associated with invasion. Copyright (C) 1999 Elsevier Science Inc.",

author = "Marta Bernu{\'e}s and Carme Casadevall and Caball{\'i}n, {M. Rosa} and Rosa Mir{\'o} and Ejarque, {M. Jos{\'e}} and Gilberto Ch{\'e}chile and Antoni Gelabert and Jos{\'e} Egozcue",

year = "1999",

month = jul,

day = "1",

doi = "10.1016/S0165-4608(98)00248-9",

language = "English",

volume = "112",

pages = "42--45",

number = "1",

}

TY - JOUR

T1 - Study of allelic losses on 3p, 6q, and 17p in human urothelial cancer

AU - Bernués, Marta

AU - Casadevall, Carme

AU - Caballín, M. Rosa

AU - Miró, Rosa

AU - Ejarque, M. José

AU - Chéchile, Gilberto

AU - Gelabert, Antoni

AU - Egozcue, José

PY - 1999/7/1

Y1 - 1999/7/1

N2 - Forty-eight transitional cell carcinomas of the bladder and three transitional cell carcinomas of the renal pelvis were examined for loss of heterozygosity (LOH) on chromosomes 3p, 6q, and 17p. The most frequent allelic loss was seen on 17p (18/36, 50%) followed by 6q (6/22, 27%), and 3p (5/22, 23%). In cases with LOH at more than one locus, the same DNA sample often varied in degree of signal reduction for missing alleles. This observation indicates that LOH studies can serve to detect intratumor heterogeneity. No correlation was found between allelic losses at these chromosome arms and tumor grade and stage. Allelic losses on 6q were associated with tumors having a solid growth pattern; in this kind of tumors, allelic losses on 3p were associated with invasion. Copyright (C) 1999 Elsevier Science Inc.

AB - Forty-eight transitional cell carcinomas of the bladder and three transitional cell carcinomas of the renal pelvis were examined for loss of heterozygosity (LOH) on chromosomes 3p, 6q, and 17p. The most frequent allelic loss was seen on 17p (18/36, 50%) followed by 6q (6/22, 27%), and 3p (5/22, 23%). In cases with LOH at more than one locus, the same DNA sample often varied in degree of signal reduction for missing alleles. This observation indicates that LOH studies can serve to detect intratumor heterogeneity. No correlation was found between allelic losses at these chromosome arms and tumor grade and stage. Allelic losses on 6q were associated with tumors having a solid growth pattern; in this kind of tumors, allelic losses on 3p were associated with invasion. Copyright (C) 1999 Elsevier Science Inc.

U2 - 10.1016/S0165-4608(98)00248-9

DO - 10.1016/S0165-4608(98)00248-9

M3 - Article

SN - 0165-4608

VL - 112

SP - 42

EP - 45

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Study of allelic losses on 3p, 6q, and 17p in human urothelial cancer

Resum

SDG de les Nacions Unides

Accés al document

Fingerprint

Com citar-ho