Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands

Hui Qiong He, Erica L. Troksa, Gianluigi Caltabiano, Leonardo Pardo, Richard D. Ye

Sortida de recercaRecercarevisió per companys

34 Cites (Scopus)

Resum

Background: Formyl peptide receptor 1 (FPR1) and FPR2 are highly homologous but bind fMet-Leu-Phe with very different affinities. Results: Asp-281 provides a negative charge that renders FPR2 more sensitive to the length and composition of formyl peptides than FPR1. Conclusion: Asp-281 is a major determinant for FPR2 binding. Significance: This work provides a structural basis for differential interaction between formyl peptides and their receptors. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Idioma originalEnglish
Pàgines (de-a)2295-2306
RevistaJournal of Biological Chemistry
Volum289
Número d'incidència4
DOIs
Estat de la publicacióPublicada - 24 de gen. 2014

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