TY - JOUR
T1 - Stereoselective Self-Assembly of DNA Binding Helicates Directed by the Viral β-Annulus Trimeric Peptide Motif
AU - Gómez-González, Jacobo
AU - Bouzada, David
AU - Pérez-Márquez, Lidia A.
AU - Sciortino, Giuseppe
AU - Maréchal, Jean Didier
AU - Vázquez López, Miguel
AU - Vázquez, M. Eugenio
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/8/18
Y1 - 2021/8/18
N2 - Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions.
AB - Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions.
UR - http://www.scopus.com/inward/record.url?scp=85112684442&partnerID=8YFLogxK
U2 - 10.1021/acs.bioconjchem.1c00312
DO - 10.1021/acs.bioconjchem.1c00312
M3 - Article
C2 - 34320309
AN - SCOPUS:85112684442
SN - 1043-1802
VL - 32
SP - 1564
EP - 1569
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 8
ER -