TY - JOUR
T1 - Stereoselective formation of chiral metallopeptides
AU - Rama, Gustavo
AU - Ardá, Ana
AU - Maréchal, Jean Didier
AU - Gamba, Ilaria
AU - Ishida, Hitoshi
AU - Jiménez-Barbero, Jesús
AU - Vázquez, M. Eugenio
AU - López, M. Vázquez
PY - 2012/6/4
Y1 - 2012/6/4
N2 - Playing into our hands: The achiral bipyridine amino acid fluorenylmethyloxycarbonyl 5-amino-3-oxapentanoic acid (Fmoc-O1PenBpy-OH) has been used for the solid-phase synthesis of metallopeptides. Circular dichroism, molecular modeling, and NMR spectroscopic studies show that the chirality of the resulting metal complexes in aqueous solution is determined, and can thus be controlled, by the stereochemistry of one proline residue in the loop between the two coordinating O1PenBpy residues. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
AB - Playing into our hands: The achiral bipyridine amino acid fluorenylmethyloxycarbonyl 5-amino-3-oxapentanoic acid (Fmoc-O1PenBpy-OH) has been used for the solid-phase synthesis of metallopeptides. Circular dichroism, molecular modeling, and NMR spectroscopic studies show that the chirality of the resulting metal complexes in aqueous solution is determined, and can thus be controlled, by the stereochemistry of one proline residue in the loop between the two coordinating O1PenBpy residues. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
KW - chirality
KW - ligand effects
KW - metallopeptides
KW - molecular modeling
KW - NMR spectroscopy
KW - peptides
UR - https://www.scopus.com/pages/publications/84861584697
U2 - 10.1002/chem.201201036
DO - 10.1002/chem.201201036
M3 - Article
SN - 0947-6539
VL - 18
SP - 7030
EP - 7035
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 23
ER -