TY - JOUR
T1 - Stereodivergent synthesis of the first bis(cyclobutane) γ-dipeptides and mixed γ-oligomers
AU - Aguilera, Jordi
AU - Moglioni, Albertina G.
AU - Moltrasio, Graciela Y.
AU - Ortuño, Rosa M.
PY - 2008/2/19
Y1 - 2008/2/19
N2 - Diastereomeric bis(cyclobutane) γ-dipeptides, a new class of γ-peptides, have been synthesized efficiently from both enantiomers of conveniently protected 3-amino-2,2-dimethyl-1-carboxylic acid. These amino acids have been prepared in very good overall yields through enantiodivergent synthetic routes starting from (-)-cis-pinononic acid. Mixed γ-oligomers have also been prepared from GABA and cyclobutane residues. © 2008 Elsevier Ltd. All rights reserved.
AB - Diastereomeric bis(cyclobutane) γ-dipeptides, a new class of γ-peptides, have been synthesized efficiently from both enantiomers of conveniently protected 3-amino-2,2-dimethyl-1-carboxylic acid. These amino acids have been prepared in very good overall yields through enantiodivergent synthetic routes starting from (-)-cis-pinononic acid. Mixed γ-oligomers have also been prepared from GABA and cyclobutane residues. © 2008 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.tetasy.2008.01.020
DO - 10.1016/j.tetasy.2008.01.020
M3 - Article
SN - 0957-4166
VL - 19
SP - 302
EP - 308
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 3
ER -