Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis

Montserrat Fusté, Iria Meléndez-Pérez, Victoria Villalta-Gil, Raquel Pinacho, Núria Villalmanzo, Narcís Cardoner, José M. Menchón, Josep Maria Haro, Carles Soriano-Mas, Belén Ramos*

*Autor corresponent d’aquest treball

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

2 Cites (Scopus)

Resum

©The Royal College of Psychiatrists 2016. We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.
Idioma originalEnglish
Pàgines (de-a)591-592
RevistaBritish Journal of Psychiatry
Volum208
Número6
DOIs
Estat de la publicacióPublicada - 1 de juny 2016

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