TY - JOUR
T1 - Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection
AU - Barmada, Anis
AU - Handfield, Louis-François
AU - Godoy-Tena, Gerard
AU - de la Calle-Fabregat, Carlos
AU - Ciudad, Laura
AU - Arutyunyan, Anna
AU - Andrés-León, Eduardo
AU - Hoo, Regina
AU - Porter, Tarryn
AU - Oszlanczi, Agnes
AU - Richardson, Laura
AU - Calero-Nieto, Fernando
AU - Wilson, Nicola K.
AU - Marchese, Domenica
AU - Sancho-Serra, Carmen
AU - Carrillo, Jorge
AU - Presas-Rodríguez, Silvia
AU - Ramo-Tello, Cristina
AU - Ruiz-Sanmartin, Adolfo
AU - Ferrer, Ricard
AU - Ruiz-Rodriguez, Juan Carlos
AU - Martínez Gallo, Mónica
AU - Munera-Campos, Mónica
AU - Carrascosa, José Manuel
AU - Göttgens, Berthold
AU - Heyn, Holger
AU - Prigmore, Elena
AU - Casafont-Solé, Ivette
AU - Solanich, Xavier
AU - Sánchez-Cerrillo, Idelfonso
AU - González-Álvaro, Isidoro
AU - Raimondo, Maria Gabriella
AU - Ramming, Andreas
AU - Martin, Javier
AU - Martínez Cáceres, Eva María
AU - Ballestar, Esteban
AU - Vento-Tormo1, Roser
AU - Rodríguez-Ubreva, Javier
N1 - © 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
PY - 2023/10/20
Y1 - 2023/10/20
N2 - In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. Here, we performed single-cell analysis of peripheral blood mononuclear cells from patients with three major autoimmune diseases (rheumatoid arthritis, psoriasis, or multiple sclerosis) during SARS-CoV-2 infection. We observed compositional differences between the autoimmune disease groups coupled with altered patterns of gene expression, transcription factor activity, and cell-cell communication that substantially shape the immune response under SARS-CoV-2 infection. While enrichment of HLA-DRlow CD14+ monocytes was observed in all three autoimmune disease groups, type-I interferon signaling as well as inflammatory T cell and monocyte responses varied widely between the three groups of patients. Our results reveal disturbed immune responses to SARS-CoV-2 in patients with pre-existing autoimmunity, highlighting important considerations for disease treatment and follow-up.
AB - In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. Here, we performed single-cell analysis of peripheral blood mononuclear cells from patients with three major autoimmune diseases (rheumatoid arthritis, psoriasis, or multiple sclerosis) during SARS-CoV-2 infection. We observed compositional differences between the autoimmune disease groups coupled with altered patterns of gene expression, transcription factor activity, and cell-cell communication that substantially shape the immune response under SARS-CoV-2 infection. While enrichment of HLA-DRlow CD14+ monocytes was observed in all three autoimmune disease groups, type-I interferon signaling as well as inflammatory T cell and monocyte responses varied widely between the three groups of patients. Our results reveal disturbed immune responses to SARS-CoV-2 in patients with pre-existing autoimmunity, highlighting important considerations for disease treatment and follow-up.
KW - Autoimmunity
KW - COVID-19
KW - Multiple sclerosis
KW - Psoriasis
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=85174260704&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/3296b34e-40b1-31b1-9eb8-98089d8df8e2/
U2 - 10.1002/eji.202350633
DO - 10.1002/eji.202350633
M3 - Article
C2 - 37799110
SN - 0014-2980
VL - 54
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 1
M1 - 2350633
ER -