Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection

Ricard Ferrer, Mónica Martínez Gallo, Eva María Martínez Cáceres, Anis Barmada, Louis-François Handfield, Gerard Godoy-Tena, Carlos de la Calle-Fabregat, Laura Ciudad, Anna Arutyunyan, Eduardo Andrés-León, Regina Hoo, Tarryn Porter, Agnes Oszlanczi, Laura Richardson, Fernando Calero-Nieto, Nicola K. Wilson, Domenica Marchese, Carmen Sancho-Serra, Jorge Carrillo, Silvia Presas-RodríguezCristina Ramo-Tello, Adolfo Ruiz-Sanmartin, Juan Carlos Ruiz-Rodriguez, Mónica Munera-Campos, José Manuel Carrascosa, Berthold Göttgens, Holger Heyn, Elena Prigmore, Ivette Casafont-Solé, Xavier Solanich, Idelfonso Sánchez-Cerrillo, Isidoro González-Álvaro, Maria Gabriella Raimondo, Andreas Ramming, Javier Martin, Esteban Ballestar, Roser Vento-Tormo1, Javier Rodríguez-Ubreva

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1 Citació (Scopus)

Resum

In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. Here, we performed single-cell analysis of peripheral blood mononuclear cells from patients with three major autoimmune diseases (rheumatoid arthritis, psoriasis, or multiple sclerosis) during SARS-CoV-2 infection. We observed compositional differences between the autoimmune disease groups coupled with altered patterns of gene expression, transcription factor activity, and cell-cell communication that substantially shape the immune response under SARS-CoV-2 infection. While enrichment of HLA-DRlow CD14+ monocytes was observed in all three autoimmune disease groups, type-I interferon signaling as well as inflammatory T cell and monocyte responses varied widely between the three groups of patients. Our results reveal disturbed immune responses to SARS-CoV-2 in patients with pre-existing autoimmunity, highlighting important considerations for disease treatment and follow-up.
Idioma originalEnglish
Número d’article2350633
RevistaEuropean Journal of Immunology
Volum54
Número1
DOIs
Estat de la publicacióPublicada - de gen. 2024

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