Simultaneous Local Heating/Thermometry Based on Plasmonic Magnetochromic Nanoheaters

Zhi Li, Alberto Lopez-Ortega, Antonio Aranda-Ramos, José Luis Tajada, Jordi Sort, Carme Nogues, Paolo Vavassori, Josep Nogues, Borja Sepulveda

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

34 Cites (Scopus)

Resum

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A crucial challenge in nanotherapies is achieving accurate and real-time control of the therapeutic action, which is particularly relevant in local thermal therapies to minimize healthy tissue damage and necrotic cell deaths. Here, a nanoheater/thermometry concept is presented based on magnetoplasmonic (Co/Au or Fe/Au) nanodomes that merge exceptionally efficient plasmonic heating and simultaneous highly sensitive detection of the temperature variations. The temperature detection is based on precise optical monitoring of the magnetic-induced rotation of the nanodomes in solution. It is shown that the phase lag between the optical signal and the driving magnetic field can be used to detect viscosity variations around the nanodomes with unprecedented accuracy (detection limit 0.0016 mPa s, i.e., 60-fold smaller than state-of-the-art plasmonic nanorheometers). This feature is exploited to monitor the viscosity reduction induced by optical heating in real-time, even in highly inhomogeneous cell dispersions. The magnetochromic nanoheater/thermometers show higher optical stability, much higher heating efficiency and similar temperature detection limits (0.05 °C) compared to state-of-the art luminescent nanothermometers. The technological interest is also boosted by the simpler and lower cost temperature detection system, and the cost effectiveness and scalability of the nanofabrication process, thereby highlighting the biomedical potential of this nanotechnology.
Idioma originalEnglish
Número d’article1800868
RevistaSmall
Volum14
Número24
DOIs
Estat de la publicacióPublicada - 14 de juny 2018

Fingerprint

Navegar pels temes de recerca de 'Simultaneous Local Heating/Thermometry Based on Plasmonic Magnetochromic Nanoheaters'. Junts formen un fingerprint únic.

Com citar-ho