Shape-switching microrobots for medical applications: The influence of shape in drug delivery and locomotion

Stefano Fusco; Hen Wei Huang; Kathrin E. Peyer; Christian Peters; Moritz Häberli; André Ulbers; Anastasia Spyrogianni; Eva Pellicer; Jordi Sort; Sotiris E. Pratsinis; Bradley J. Nelson; Mahmut Selman Sakar; Salvador Pané

doi:10.1021/acsami.5b00181

Shape-switching microrobots for medical applications: The influence of shape in drug delivery and locomotion

Stefano Fusco, Hen Wei Huang, Kathrin E. Peyer, Christian Peters, Moritz Häberli, André Ulbers, Anastasia Spyrogianni, Eva Pellicer, Jordi Sort, Sotiris E. Pratsinis, Bradley J. Nelson, Mahmut Selman Sakar, Salvador Pané

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© 2015 American Chemical Society. The effect of dynamic shape switching of hydrogel bilayers on the performance of self-folding microrobots is investigated for navigation in body orifices and drug release on demand. Tubular microrobots are fabricated by coupling a thermoresponsive hydrogel nanocomposite with a poly(ethylene glycol)diacrylate (PEGDA) layer, to achieve spontaneous and reversible folding from a planar rectangular structure. Graphene oxide (GO) or silica-coated superparamagnetic iron oxide nanoparticles are dispersed in the thermoresponsive hydrogel matrix to provide near-infrared (NIR) light sensitivity or magnetic actuation, respectively. The NIR light-responsive microstructures are fabricated for triggered drug delivery while magnetic nanocomposite-based microrobots are used to analyze the role of shape in locomotion. Experimental analysis and computational simulations of tubular structures show that drug release and motility can be optimized through controlled shape change. These concepts are finally applied to helical microrobots to show a possible way to achieve autonomous behavior.

Idioma original	Anglès
Pàgines (de-a)	6803-6811
Revista	ACS applied materials & interfaces
Volum	7
DOIs	https://doi.org/10.1021/acsami.5b00181
Estat de la publicació	Publicada - 1 de gen. 2015

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10.1021/acsami.5b00181

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Fusco, S., Huang, H. W., Peyer, K. E., Peters, C., Häberli, M., Ulbers, A., Spyrogianni, A., Pellicer, E., Sort, J., Pratsinis, S. E., Nelson, B. J., Sakar, M. S., & Pané, S. (2015). Shape-switching microrobots for medical applications: The influence of shape in drug delivery and locomotion. ACS applied materials & interfaces, 7, 6803-6811. https://doi.org/10.1021/acsami.5b00181

@article{3a017876b78c471489627a412e029bcb,

title = "Shape-switching microrobots for medical applications: The influence of shape in drug delivery and locomotion",

abstract = "{\textcopyright} 2015 American Chemical Society. The effect of dynamic shape switching of hydrogel bilayers on the performance of self-folding microrobots is investigated for navigation in body orifices and drug release on demand. Tubular microrobots are fabricated by coupling a thermoresponsive hydrogel nanocomposite with a poly(ethylene glycol)diacrylate (PEGDA) layer, to achieve spontaneous and reversible folding from a planar rectangular structure. Graphene oxide (GO) or silica-coated superparamagnetic iron oxide nanoparticles are dispersed in the thermoresponsive hydrogel matrix to provide near-infrared (NIR) light sensitivity or magnetic actuation, respectively. The NIR light-responsive microstructures are fabricated for triggered drug delivery while magnetic nanocomposite-based microrobots are used to analyze the role of shape in locomotion. Experimental analysis and computational simulations of tubular structures show that drug release and motility can be optimized through controlled shape change. These concepts are finally applied to helical microrobots to show a possible way to achieve autonomous behavior.",

keywords = "drug delivery, hydrogel nanocomposites, magnetic manipulation, microrobotics, self-folding bilayers",

author = "Stefano Fusco and Huang, {Hen Wei} and Peyer, {Kathrin E.} and Christian Peters and Moritz H{\"a}berli and Andr{\'e} Ulbers and Anastasia Spyrogianni and Eva Pellicer and Jordi Sort and Pratsinis, {Sotiris E.} and Nelson, {Bradley J.} and Sakar, {Mahmut Selman} and Salvador Pan{\'e}",

year = "2015",

month = jan,

day = "1",

doi = "10.1021/acsami.5b00181",

language = "English",

volume = "7",

pages = "6803--6811",

journal = "ACS applied materials & interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

}

Fusco, S, Huang, HW, Peyer, KE, Peters, C, Häberli, M, Ulbers, A, Spyrogianni, A, Pellicer, E , Sort, J, Pratsinis, SE, Nelson, BJ, Sakar, MS & Pané, S 2015, 'Shape-switching microrobots for medical applications: The influence of shape in drug delivery and locomotion', ACS applied materials & interfaces, vol. 7, pàg. 6803-6811. https://doi.org/10.1021/acsami.5b00181

TY - JOUR

T1 - Shape-switching microrobots for medical applications: The influence of shape in drug delivery and locomotion

AU - Fusco, Stefano

AU - Huang, Hen Wei

AU - Peyer, Kathrin E.

AU - Peters, Christian

AU - Häberli, Moritz

AU - Ulbers, André

AU - Spyrogianni, Anastasia

AU - Pellicer, Eva

AU - Sort, Jordi

AU - Pratsinis, Sotiris E.

AU - Nelson, Bradley J.

AU - Sakar, Mahmut Selman

AU - Pané, Salvador

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2015 American Chemical Society. The effect of dynamic shape switching of hydrogel bilayers on the performance of self-folding microrobots is investigated for navigation in body orifices and drug release on demand. Tubular microrobots are fabricated by coupling a thermoresponsive hydrogel nanocomposite with a poly(ethylene glycol)diacrylate (PEGDA) layer, to achieve spontaneous and reversible folding from a planar rectangular structure. Graphene oxide (GO) or silica-coated superparamagnetic iron oxide nanoparticles are dispersed in the thermoresponsive hydrogel matrix to provide near-infrared (NIR) light sensitivity or magnetic actuation, respectively. The NIR light-responsive microstructures are fabricated for triggered drug delivery while magnetic nanocomposite-based microrobots are used to analyze the role of shape in locomotion. Experimental analysis and computational simulations of tubular structures show that drug release and motility can be optimized through controlled shape change. These concepts are finally applied to helical microrobots to show a possible way to achieve autonomous behavior.

AB - © 2015 American Chemical Society. The effect of dynamic shape switching of hydrogel bilayers on the performance of self-folding microrobots is investigated for navigation in body orifices and drug release on demand. Tubular microrobots are fabricated by coupling a thermoresponsive hydrogel nanocomposite with a poly(ethylene glycol)diacrylate (PEGDA) layer, to achieve spontaneous and reversible folding from a planar rectangular structure. Graphene oxide (GO) or silica-coated superparamagnetic iron oxide nanoparticles are dispersed in the thermoresponsive hydrogel matrix to provide near-infrared (NIR) light sensitivity or magnetic actuation, respectively. The NIR light-responsive microstructures are fabricated for triggered drug delivery while magnetic nanocomposite-based microrobots are used to analyze the role of shape in locomotion. Experimental analysis and computational simulations of tubular structures show that drug release and motility can be optimized through controlled shape change. These concepts are finally applied to helical microrobots to show a possible way to achieve autonomous behavior.

KW - drug delivery

KW - hydrogel nanocomposites

KW - magnetic manipulation

KW - microrobotics

KW - self-folding bilayers

U2 - 10.1021/acsami.5b00181

DO - 10.1021/acsami.5b00181

M3 - Article

SN - 1944-8244

VL - 7

SP - 6803

EP - 6811

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

ER -

Shape-switching microrobots for medical applications: The influence of shape in drug delivery and locomotion

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