Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

Giulio Disanto; Rocco Adiutori; Ruth Dobson; Vittorio Martinelli; Gloria Dalla Costa; Tessel Runia; Evgeniy Evdoshenko; Eric Thouvenot; Maria Trojano; Niklas Norgren; Charlotte Teunissen; Ludwig Kappos; Gavin Giovannoni; Jens Kuhle; Lucia Bianchi; Joanne Topping; Jonathan P. Bestwick; Ute-Christiane Meier; Natalia Lazareva; Pietro Iaffaldano; Vita Direnzo; Mohsen Khademi; Fredrik Piehl; Manuel Comabella; Madeleine Sombekke; Joep Killestein; Harald Hegen; Stefan Rauch; Sandra D'Alfonso; Jose C. Alvarez-Cermeno; Pavlina Kleinova; Dana Horakova; Romy Roesler; Florian Lauda; Sara Llufriu; Timucin Avsar; Ugur Uygunoglu; Ayse Altintas; Sabahattin Saip; Til Menge; Cecilia Rajda; Roberto Bergamaschi; Natalia Moll; Michael Khalil; Romain Marignier; Irena Dujmovic; Henrik Larsson; Clas Malmestrom; Elio Scarpini; Chiara Fenoglio; Stig Wergeland; Alice Laroni; Viviana Annibali; Silvia Romano; Alejandra D. Martinez; Adriana Carra; Marco Salvetti; Antonio Uccelli; Oivind Torkildsen; KjellMorten Myhr; Daniela Galimberti; Konrad Rejdak; Jan Lycke; Jette L. Frederiksen; Jelena Drulovic; Christian Confavreux; David Brassat; Christian Enzinger; Siegrid Fuchs; Isabel Bosca; Jean Pelletier; Christophe Picard; Elena Colombo; Diego Franciotta; Tobias Derfuss; Raija L. P. Lindberg; Ozgur Yaldizli; Laszlo Vecsei; Bernd C. Kieseier; Hans Peter Hartung; Pablo Villoslada; Aksel Siva; Albert Saiz; Hayrettin Tumani; Eva Havrdova; Luisa M. Villar; Maurizio Leone; Nadia Barizzone; Florian Deisenhammer; Xavier Montalban; Mar Tintore; Tomas Olsson; Sylvain Lehmann; Giovanni Castelnovo; Sergey Lapin; Rogier Hintzen; Roberto Furlan; Giancarlo Comi; Sreeram V. Ramagopalan

doi:10.1136/jnnp-2014-309690

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

Giulio Disanto, Rocco Adiutori, Ruth Dobson, Vittorio Martinelli, Gloria Dalla Costa, Tessel Runia, Evgeniy Evdoshenko, Eric Thouvenot, Maria Trojano, Niklas Norgren, Charlotte Teunissen, Ludwig Kappos, Gavin Giovannoni, Jens Kuhle, Lucia Bianchi, Joanne Topping, Jonathan P. Bestwick, Ute-Christiane Meier, Natalia Lazareva, Pietro IaffaldanoVita Direnzo, Mohsen Khademi, Fredrik Piehl, Manuel Comabella, Madeleine Sombekke, Joep Killestein, Harald Hegen, Stefan Rauch, Sandra D'Alfonso, Jose C. Alvarez-Cermeno, Pavlina Kleinova, Dana Horakova, Romy Roesler, Florian Lauda, Sara Llufriu, Timucin Avsar, Ugur Uygunoglu, Ayse Altintas, Sabahattin Saip, Til Menge, Cecilia Rajda, Roberto Bergamaschi, Natalia Moll, Michael Khalil, Romain Marignier, Irena Dujmovic, Henrik Larsson, Clas Malmestrom, Elio Scarpini, Chiara Fenoglio, Stig Wergeland, Alice Laroni, Viviana Annibali, Silvia Romano, Alejandra D. Martinez, Adriana Carra, Marco Salvetti, Antonio Uccelli, Oivind Torkildsen, KjellMorten Myhr, Daniela Galimberti, Konrad Rejdak, Jan Lycke, Jette L. Frederiksen, Jelena Drulovic, Christian Confavreux, David Brassat, Christian Enzinger, Siegrid Fuchs, Isabel Bosca, Jean Pelletier, Christophe Picard, Elena Colombo, Diego Franciotta, Tobias Derfuss, Raija L. P. Lindberg, Ozgur Yaldizli, Laszlo Vecsei, Bernd C. Kieseier, Hans Peter Hartung, Pablo Villoslada, Aksel Siva, Albert Saiz, Hayrettin Tumani, Eva Havrdova, Luisa M. Villar, Maurizio Leone, Nadia Barizzone, Florian Deisenhammer, Xavier Montalban, Mar Tintore, Tomas Olsson, Sylvain Lehmann, Giovanni Castelnovo, Sergey Lapin, Rogier Hintzen, Roberto Furlan, Giancarlo Comi, Sreeram V. Ramagopalan

Departament de Medicina

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Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls.Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls.Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5x10(-5) and OR=7.03; 95% CI 2.85 to 17.34; p=2.3x10(-5), respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis.Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.

Idioma original	Anglès
Pàgines (de-a)	126-129
Nombre de pàgines	4
Revista	Journal of Neurology Neurosurgery and Psychiatry
Volum	87
Número	2
DOIs	https://doi.org/10.1136/jnnp-2014-309690
Estat de la publicació	Publicada - de febr. 2016

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10.1136/jnnp-2014-309690

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Disanto, G., Adiutori, R., Dobson, R., Martinelli, V., Costa, G. D., Runia, T., Evdoshenko, E., Thouvenot, E., Trojano, M., Norgren, N., Teunissen, C., Kappos, L., Giovannoni, G., Kuhle, J., Bianchi, L., Topping, J., Bestwick, J. P., Meier, U.-C., Lazareva, N., ... Ramagopalan, S. V. (2016). Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome. Journal of Neurology Neurosurgery and Psychiatry, 87(2), 126-129. https://doi.org/10.1136/jnnp-2014-309690

@article{54c85003a11749a580cb63cd03d60eb1,

title = "Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome",

abstract = "Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls.Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls.Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5x10(-5) and OR=7.03; 95% CI 2.85 to 17.34; p=2.3x10(-5), respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis.Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.",

keywords = "Multiple-sclerosis, Cerebrospinal-fluid, N-acetylaspartate, Csf neurofilament, Protein",

author = "Giulio Disanto and Rocco Adiutori and Ruth Dobson and Vittorio Martinelli and Costa, {Gloria Dalla} and Tessel Runia and Evgeniy Evdoshenko and Eric Thouvenot and Maria Trojano and Niklas Norgren and Charlotte Teunissen and Ludwig Kappos and Gavin Giovannoni and Jens Kuhle and Lucia Bianchi and Joanne Topping and Bestwick, {Jonathan P.} and Ute-Christiane Meier and Natalia Lazareva and Pietro Iaffaldano and Vita Direnzo and Mohsen Khademi and Fredrik Piehl and Manuel Comabella and Madeleine Sombekke and Joep Killestein and Harald Hegen and Stefan Rauch and Sandra D'Alfonso and Alvarez-Cermeno, {Jose C.} and Pavlina Kleinova and Dana Horakova and Romy Roesler and Florian Lauda and Sara Llufriu and Timucin Avsar and Ugur Uygunoglu and Ayse Altintas and Sabahattin Saip and Til Menge and Cecilia Rajda and Roberto Bergamaschi and Natalia Moll and Michael Khalil and Romain Marignier and Irena Dujmovic and Henrik Larsson and Clas Malmestrom and Elio Scarpini and Chiara Fenoglio and Stig Wergeland and Alice Laroni and Viviana Annibali and Silvia Romano and Martinez, {Alejandra D.} and Adriana Carra and Marco Salvetti and Antonio Uccelli and Oivind Torkildsen and KjellMorten Myhr and Daniela Galimberti and Konrad Rejdak and Jan Lycke and Frederiksen, {Jette L.} and Jelena Drulovic and Christian Confavreux and David Brassat and Christian Enzinger and Siegrid Fuchs and Isabel Bosca and Jean Pelletier and Christophe Picard and Elena Colombo and Diego Franciotta and Tobias Derfuss and Lindberg, {Raija L. P.} and Ozgur Yaldizli and Laszlo Vecsei and Kieseier, {Bernd C.} and Hartung, {Hans Peter} and Pablo Villoslada and Aksel Siva and Albert Saiz and Hayrettin Tumani and Eva Havrdova and Villar, {Luisa M.} and Maurizio Leone and Nadia Barizzone and Florian Deisenhammer and Xavier Montalban and Mar Tintore and Tomas Olsson and Sylvain Lehmann and Giovanni Castelnovo and Sergey Lapin and Rogier Hintzen and Roberto Furlan and Giancarlo Comi and Ramagopalan, {Sreeram V.}",

year = "2016",

month = feb,

doi = "10.1136/jnnp-2014-309690",

language = "English",

volume = "87",

pages = "126--129",

journal = "Journal of Neurology Neurosurgery and Psychiatry",

issn = "0022-3050",

publisher = "BMJ Publishing Group",

number = "2",

}

Disanto, G, Adiutori, R, Dobson, R, Martinelli, V, Costa, GD, Runia, T, Evdoshenko, E, Thouvenot, E, Trojano, M, Norgren, N, Teunissen, C, Kappos, L, Giovannoni, G, Kuhle, J, Bianchi, L, Topping, J, Bestwick, JP, Meier, U-C, Lazareva, N, Iaffaldano, P, Direnzo, V, Khademi, M, Piehl, F, Comabella, M, Sombekke, M, Killestein, J, Hegen, H, Rauch, S, D'Alfonso, S, Alvarez-Cermeno, JC, Kleinova, P, Horakova, D, Roesler, R, Lauda, F, Llufriu, S, Avsar, T, Uygunoglu, U, Altintas, A, Saip, S, Menge, T, Rajda, C, Bergamaschi, R, Moll, N, Khalil, M, Marignier, R, Dujmovic, I, Larsson, H, Malmestrom, C, Scarpini, E, Fenoglio, C, Wergeland, S, Laroni, A, Annibali, V, Romano, S, Martinez, AD, Carra, A, Salvetti, M, Uccelli, A, Torkildsen, O, Myhr, K, Galimberti, D, Rejdak, K, Lycke, J, Frederiksen, JL, Drulovic, J, Confavreux, C, Brassat, D, Enzinger, C, Fuchs, S, Bosca, I, Pelletier, J, Picard, C, Colombo, E, Franciotta, D, Derfuss, T, Lindberg, RLP, Yaldizli, O, Vecsei, L, Kieseier, BC, Hartung, HP, Villoslada, P, Siva, A, Saiz, A, Tumani, H, Havrdova, E, Villar, LM, Leone, M, Barizzone, N, Deisenhammer, F, Montalban, X, Tintore, M, Olsson, T, Lehmann, S, Castelnovo, G, Lapin, S, Hintzen, R, Furlan, R, Comi, G & Ramagopalan, SV 2016, 'Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome', Journal of Neurology Neurosurgery and Psychiatry, vol. 87, núm. 2, pàg. 126-129. https://doi.org/10.1136/jnnp-2014-309690

TY - JOUR

T1 - Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

AU - Disanto, Giulio

AU - Adiutori, Rocco

AU - Dobson, Ruth

AU - Martinelli, Vittorio

AU - Costa, Gloria Dalla

AU - Runia, Tessel

AU - Evdoshenko, Evgeniy

AU - Thouvenot, Eric

AU - Trojano, Maria

AU - Norgren, Niklas

AU - Teunissen, Charlotte

AU - Kappos, Ludwig

AU - Giovannoni, Gavin

AU - Kuhle, Jens

AU - Bianchi, Lucia

AU - Topping, Joanne

AU - Bestwick, Jonathan P.

AU - Meier, Ute-Christiane

AU - Lazareva, Natalia

AU - Iaffaldano, Pietro

AU - Direnzo, Vita

AU - Khademi, Mohsen

AU - Piehl, Fredrik

AU - Comabella, Manuel

AU - Sombekke, Madeleine

AU - Killestein, Joep

AU - Hegen, Harald

AU - Rauch, Stefan

AU - D'Alfonso, Sandra

AU - Alvarez-Cermeno, Jose C.

AU - Kleinova, Pavlina

AU - Horakova, Dana

AU - Roesler, Romy

AU - Lauda, Florian

AU - Llufriu, Sara

AU - Avsar, Timucin

AU - Uygunoglu, Ugur

AU - Altintas, Ayse

AU - Saip, Sabahattin

AU - Menge, Til

AU - Rajda, Cecilia

AU - Bergamaschi, Roberto

AU - Moll, Natalia

AU - Khalil, Michael

AU - Marignier, Romain

AU - Dujmovic, Irena

AU - Larsson, Henrik

AU - Malmestrom, Clas

AU - Scarpini, Elio

AU - Fenoglio, Chiara

AU - Wergeland, Stig

AU - Laroni, Alice

AU - Annibali, Viviana

AU - Romano, Silvia

AU - Martinez, Alejandra D.

AU - Carra, Adriana

AU - Salvetti, Marco

AU - Uccelli, Antonio

AU - Torkildsen, Oivind

AU - Myhr, KjellMorten

AU - Galimberti, Daniela

AU - Rejdak, Konrad

AU - Lycke, Jan

AU - Frederiksen, Jette L.

AU - Drulovic, Jelena

AU - Confavreux, Christian

AU - Brassat, David

AU - Enzinger, Christian

AU - Fuchs, Siegrid

AU - Bosca, Isabel

AU - Pelletier, Jean

AU - Picard, Christophe

AU - Colombo, Elena

AU - Franciotta, Diego

AU - Derfuss, Tobias

AU - Lindberg, Raija L. P.

AU - Yaldizli, Ozgur

AU - Vecsei, Laszlo

AU - Kieseier, Bernd C.

AU - Hartung, Hans Peter

AU - Villoslada, Pablo

AU - Siva, Aksel

AU - Saiz, Albert

AU - Tumani, Hayrettin

AU - Havrdova, Eva

AU - Villar, Luisa M.

AU - Leone, Maurizio

AU - Barizzone, Nadia

AU - Deisenhammer, Florian

AU - Montalban, Xavier

AU - Tintore, Mar

AU - Olsson, Tomas

AU - Lehmann, Sylvain

AU - Castelnovo, Giovanni

AU - Lapin, Sergey

AU - Hintzen, Rogier

AU - Furlan, Roberto

AU - Comi, Giancarlo

AU - Ramagopalan, Sreeram V.

PY - 2016/2

Y1 - 2016/2

N2 - Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls.Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls.Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5x10(-5) and OR=7.03; 95% CI 2.85 to 17.34; p=2.3x10(-5), respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis.Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.

AB - Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls.Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls.Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5x10(-5) and OR=7.03; 95% CI 2.85 to 17.34; p=2.3x10(-5), respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis.Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.

KW - Multiple-sclerosis

KW - Cerebrospinal-fluid

KW - N-acetylaspartate

KW - Csf neurofilament

KW - Protein

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=uab_pure&SrcAuth=WosAPI&KeyUT=WOS:000368175000004&DestLinkType=FullRecord&DestApp=WOS

U2 - 10.1136/jnnp-2014-309690

DO - 10.1136/jnnp-2014-309690

M3 - Article

C2 - 25716934

SN - 0022-3050

VL - 87

SP - 126

EP - 129

JO - Journal of Neurology Neurosurgery and Psychiatry

JF - Journal of Neurology Neurosurgery and Psychiatry

IS - 2

ER -

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

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