TY - JOUR
T1 - Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease
AU - Remuzgo-Martínez, Sara
AU - Genre, Fernanda
AU - Pulito-Cueto, Verónica
AU - Atienza-Mateo, Belén
AU - Mora Cuesta, Víctor Manuel
AU - Iturbe, David
AU - Fernández Rozas, Sonia María
AU - Lera-Gómez, Leticia
AU - Alonso Lecue, Pilar
AU - Ussetti, María Piedad
AU - Laporta, Rosalía
AU - Berastegui García, Cristina
AU - Solé, Amparo
AU - Pérez González, Virginia Luz
AU - De Pablo Gafas, Alicia
AU - Gualillo, Oreste
AU - Cifrián, José Manuel
AU - López-Mejías, Raquel
AU - Gonzalez-Gay, MA
PY - 2021
Y1 - 2021
N2 - The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients
AB - The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients
KW - Interstitial lung disease
KW - Idiopathic interstitial pneumonia
KW - Vascular endothelial growth factor
KW - Biomarker
KW - Genetics
U2 - 10.3390/biomedicines9050458
DO - 10.3390/biomedicines9050458
M3 - Article
C2 - 33922301
SN - 2227-9059
VL - 9
JO - Biomedicines
JF - Biomedicines
ER -