Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

Susana Campoy; Mónica Jara; Núria Busquets; Ana M. Pérez De Rozas; Ignacio Badiola; Jordi Barbé

doi:10.1128/IAI.70.8.4721-4725.2002

Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

Susana Campoy, Mónica Jara, Núria Busquets, Ana M. Pérez De Rozas, Ignacio Badiola, Jordi Barbé

Departament de Genètica i de Microbiologia

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

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Resum

The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.

Idioma original	Anglès
Pàgines (de-a)	4721-4725
Revista	Infection and Immunity
Volum	70
Número	8
DOIs	https://doi.org/10.1128/IAI.70.8.4721-4725.2002
Estat de la publicació	Publicada - 30 de jul. 2002

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10.1128/IAI.70.8.4721-4725.2002

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title = "Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence",

abstract = "The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.",

author = "Susana Campoy and M{\'o}nica Jara and N{\'u}ria Busquets and {P{\'e}rez De Rozas}, {Ana M.} and Ignacio Badiola and Jordi Barb{\'e}",

year = "2002",

month = jul,

day = "30",

doi = "10.1128/IAI.70.8.4721-4725.2002",

language = "English",

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journal = "Infection and Immunity",

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TY - JOUR

T1 - Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

AU - Campoy, Susana

AU - Jara, Mónica

AU - Busquets, Núria

AU - Pérez De Rozas, Ana M.

AU - Badiola, Ignacio

AU - Barbé, Jordi

PY - 2002/7/30

Y1 - 2002/7/30

N2 - The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.

AB - The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.

U2 - 10.1128/IAI.70.8.4721-4725.2002

DO - 10.1128/IAI.70.8.4721-4725.2002

M3 - Article

SN - 0019-9567

VL - 70

SP - 4721

EP - 4725

JO - Infection and Immunity

JF - Infection and Immunity

IS - 8

ER -

Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

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