Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease

A. Seoane, X. Bessa, F. Alameda, A. Munné, M. Gallen, S. Navarro, E. O'Callaghan, A. Panadès, M. Andreu, F. Bory

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Objective: to determine the prevalence of Helicobacter pylori infection in patients having undergone gastrectomy for non-neoplastic disease who later developed gastric stump cancer. Material and methods: retrospective study of all patients with partial gastrectomy for non-malignant peptic disease who were submitted to an endoscopic exploration between 1995 and 2001. A comparison was made of major clinical and histological characteristics, and the presence of Helicobacter pylori among patients with and without gastric cancer in the stomach remnant. Results: a total of 73 patients were studied in this period. Fifteen patients (20.5%) had remnant-stump gastric cancer. All but one were adenocarcinomas (71% intestinal and 29% diffuse, respectively). The average time between diagnosis of gastric cancer and previous gastrectomy was 32 (14-48) years. There was a higher detection rate of Helicobacter pylori in patients with cancer in the gastric remnant (100 vs. 81.5%, respectively, p < 0.07). No relationship was seen between type of gastric reconstruction (Billroth I or II) and rate of Helicobacter pylori detection. Conclusions: Helicobacter pylori infection is frequent in patients with previous gastrectomy for non-neoplastic disease. The results of the study suggest that Helicobacter pylori infection may play a role in gastric stump cancer. Copyright © 2005 Arán Ediciones, S. L.
Idioma originalAnglès
Pàgines (de-a)778-785
RevistaRevista Española de Enfermedades Digestivas
Volum97
Número11
DOIs
Estat de la publicacióPublicada - 1 de gen. 2005

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