RhoE is required for contact inhibition and negatively regulates tumor initiation and progression

Marta Hernández-Sánchez, Enric Poch, Rosa M. Guasch, Joaquín Ortega, Inmaculada López-Almela, Ignacio Palmero, Ignacio Pérez-Roger

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Resum

RhoE is a small GTPase involved in the regulation of actin cytoskeleton dynamics, cell cycle and apoptosis. The role of RhoE in cancer is currently controversial, with reports of both oncogenic and tumor-suppressive functions for RhoE. Using RhoE-deficient mice, we show here that the absence of RhoE blunts contact-inhibition of growth by inhibiting p27Kip1 nuclear translocation and cooperates in oncogenic transformation of mouse primary fibroblasts. Heterozygous RhoE+/gt mice are more susceptible to chemically induced skin tumors and RhoE knock-down results in increased metastatic potential of cancer cells. These results indicate that RhoE plays a role in suppressing tumor initiation and progression.
Idioma originalEnglish
Pàgines (de-a)17479-17490
RevistaOncotarget
Volum6
Número19
DOIs
Estat de la publicacióPublicada - 1 de gen. 2015

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