TY - JOUR
T1 - Retrosynthetic Analysis Applied to Clip-off Chemistry :
T2 - Synthesis of Four Rh(II)-Based Complexes as Proof-of-Concept
AU - Broto-Ribas, Anna
AU - Ruiz Relaño, Sara
AU - Albalad, Jorge
AU - Yang, Yunhui
AU - Gándara, Felipe
AU - Juanhuix, Judith
AU - Imaz, Inhar
AU - Maspoch Comamala, Daniel
N1 - Publisher Copyright:
© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
PY - 2023/11/27
Y1 - 2023/11/27
N2 - Clip-off Chemistry is a synthetic strategy that our group previously developed to obtain new molecules and materials through selective cleavage of bonds. Herein, we report recent work to expand Clip-off Chemistry by introducing into it a retrosynthetic analysis step that, based on virtual extension of the products through cleavable bonds, enables one to define the required precursor materials. As proof-of-concept, we have validated our new approach by synthesising and characterising four aldehyde-functionalised Rh(II)-based complexes: a homoleptic cluster; a cis-disubstituted paddlewheel cluster; a macrocycle; and a crown.In Clip-off Chemistry, a retrosynthetic analysis step based on virtual extension of the products through cleavable bonds enables defining the required precursor materials. As proof-of-concept, this new approach is used to synthesize four aldehyde-functionalised Rh(II)-based complexes: a homoleptic cluster; a cis-disubstituted paddlewheel cluster; a macrocycle; and a crown.+image
AB - Clip-off Chemistry is a synthetic strategy that our group previously developed to obtain new molecules and materials through selective cleavage of bonds. Herein, we report recent work to expand Clip-off Chemistry by introducing into it a retrosynthetic analysis step that, based on virtual extension of the products through cleavable bonds, enables one to define the required precursor materials. As proof-of-concept, we have validated our new approach by synthesising and characterising four aldehyde-functionalised Rh(II)-based complexes: a homoleptic cluster; a cis-disubstituted paddlewheel cluster; a macrocycle; and a crown.In Clip-off Chemistry, a retrosynthetic analysis step based on virtual extension of the products through cleavable bonds enables defining the required precursor materials. As proof-of-concept, this new approach is used to synthesize four aldehyde-functionalised Rh(II)-based complexes: a homoleptic cluster; a cis-disubstituted paddlewheel cluster; a macrocycle; and a crown.+image
KW - Bond Breaking
KW - Clip-off Chemistry
KW - Disassembly
KW - Metal-Organic Polyhedra
KW - Retrosynthetic Analysis
UR - http://www.scopus.com/inward/record.url?scp=85171457113&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/b8e4027e-4517-3821-ac2f-f1b33cea0e08/
U2 - 10.1002/anie.202310354
DO - 10.1002/anie.202310354
M3 - Article
C2 - 37671919
SN - 1433-7851
VL - 62
SP - e202310354
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 48
M1 - e202310354
ER -