Removal of dolutegravir by hemodialysis in HIV-Infected patients with end-stage renal disease

José Moltó, Fredzzia Graterol, Cristina Miranda, Saye Khoo, D. Ioana Bancu, Alieu Amara, Anna Bonjoch, Bonaventura Clotet

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Resum

Copyright © 2016, American Society for Microbiology. All Rights Reserved. Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting.
Idioma originalEnglish
Pàgines (de-a)2564-2566
RevistaAntimicrobial Agents and Chemotherapy
Volum60
Número4
DOIs
Estat de la publicacióPublicada - 1 d’abr. 2016

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