Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis

Ana Catalan; Stefania Tognin; Matthew J. Kempton; Daniel Stahl; Gonzalo Salazar de Pablo; Barnaby Nelson; Christos Pantelis; Anita Riecher-Rössler; Rodrigo Bressan; Neus Barrantes-Vidal; Marie Odile Krebs; Merete Nordentoft; Stephan Ruhrmann; Gabriele Sachs; Bart P.F. Rutten; Jim van Os; Lieuwe de Haan; Mark van der Gaag; Lucia R. Valmaggia; Philip McGuire; Tecelli Dominguez Martinez; Anna Racioppi; Thomas Kwapil; Manel Monsonet Bardaji; Lídia Hinojosa Marqués; M Kazes; C Daban; J Bourgin; Célia Jantac; Marie Odile Krebs; Dorte Nordholm; Lasse Randers; Kristine Krakauer; Louise Birkedal Glenthøj; Birte Glenthøj; Merete Nordentoft; Stephan Ruhrmann; Dominika Gebhard; Julia Arnhold; Joachim Klosterkötter; G Sachs; I Lasser; B Winklbaur; Philippe Delespaul; Bart P.F. Rutten; J. Van Os

doi:10.1017/S0033291720003396

Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis

Ana Catalan^*, Stefania Tognin, Matthew J. Kempton, Daniel Stahl, Gonzalo Salazar de Pablo, Barnaby Nelson, Christos Pantelis, Anita Riecher-Rössler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P.F. Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Lucia R. Valmaggia, Philip McGuire^*, Tecelli Dominguez Martinez, Anna Racioppi , Thomas Kwapil, Manel Monsonet Bardaji, Lídia Hinojosa Marqués, M Kazes, C Daban, J Bourgin, Célia Jantac, Marie Odile Krebs, Dorte Nordholm, Lasse Randers, Kristine Krakauer, Louise Birkedal Glenthøj, Birte Glenthøj, Merete Nordentoft, Stephan Ruhrmann, Dominika Gebhard, Julia Arnhold, Joachim Klosterkötter, G Sachs, I Lasser, B Winklbaur, Philippe Delespaul, Bart P.F. Rutten, J. Van Os

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Resum

Background. Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods. In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. Results. There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; χ2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ.

Idioma original	Anglès nord-americà
Revista	Psychological Medicine
DOIs	https://doi.org/10.1017/S0033291720003396
Estat de la publicació	Publicada - d’oct. 2020

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Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

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10.1017/S0033291720003396

https://ddd.uab.cat/record/280559

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Link to publication in Scopus

Trayectorias de riesgo y resiliencia a la psicosis: estudio integrador de las interacciones gen-persona-ambiente en el fenotipo extenso de la psicosis
Vidal Barrantes, N. (Investigador/a principal), Cristobal Narvaez, P. (Col.laborador/a), Kwapil, T. R. (Col.laborador/a), Myinn-Gemeys, I. (Col.laborador/a), Ballespi Sola, S. (Investigador/a), Monsonet Bardaji, M. (Col.laborador/a), Sheinbaum Frank, T. (Col.laborador/a), Torices, I. (Col.laborador/a), Dominguez Martínez, T. (Col.laborador/a), Montoro Lus, M. (Col.laborador/a), Herrera López, S. (Col.laborador/a), Torrecilla Gonzalez, P. (Col.laborador/a), Gizdic , A. (Col.laborador/a), Hinojosa Marqués, L. (Col.laborador/a) & Racioppi, A. (Col.laborador/a)
Ministerio de Economía y Competitividad (MINECO), Ministerio de Ciencia e Innovación (MICINN)
1/01/18 → 28/02/22
Projecte: Projectes i Ajuts a la Recerca

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Catalan, A., Tognin, S., Kempton, M. J., Stahl, D., de Pablo, G. S., Nelson, B., Pantelis, C., Riecher-Rössler, A., Bressan, R., Barrantes-Vidal, N., Krebs, M. O., Nordentoft, M., Ruhrmann, S., Sachs, G., Rutten, B. P. F., van Os, J., de Haan, L., van der Gaag, M., Valmaggia, L. R., ... Van Os, J. (2020). Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis. Psychological Medicine. https://doi.org/10.1017/S0033291720003396

@article{f8d624bee0e84840b7119df70d12f54b,

title = "Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis",

abstract = "Background. Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods. In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1\%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. Results. There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17\%; χ2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ.",

keywords = "Functioning, Psychosis, Transition to psychosis, Ultra high-risk",

author = "Ana Catalan and Stefania Tognin and Kempton, \{Matthew J.\} and Daniel Stahl and \{de Pablo\}, \{Gonzalo Salazar\} and Barnaby Nelson and Christos Pantelis and Anita Riecher-R{\"o}ssler and Rodrigo Bressan and Neus Barrantes-Vidal and Krebs, \{Marie Odile\} and Merete Nordentoft and Stephan Ruhrmann and Gabriele Sachs and Rutten, \{Bart P.F.\} and \{van Os\}, Jim and \{de Haan\}, Lieuwe and \{van der Gaag\}, Mark and Valmaggia, \{Lucia R.\} and Philip McGuire and \{Dominguez Martinez\}, Tecelli and Anna Racioppi and Thomas Kwapil and \{Monsonet Bardaji\}, Manel and \{Hinojosa Marqu{\'e}s\}, L{\'i}dia and M Kazes and C Daban and J Bourgin and C{\'e}lia Jantac and Krebs, \{Marie Odile\} and Dorte Nordholm and Lasse Randers and Kristine Krakauer and Glenth{\o}j, \{Louise Birkedal\} and Birte Glenth{\o}j and Merete Nordentoft and Stephan Ruhrmann and Dominika Gebhard and Julia Arnhold and Joachim Klosterk{\"o}tter and G Sachs and I Lasser and B Winklbaur and Philippe Delespaul and Rutten, \{Bart P.F.\} and \{Van Os\}, J.",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2020. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = oct,

doi = "10.1017/S0033291720003396",

language = "Ingl{\'e}s estadounidense",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

}

Catalan, A, Tognin, S, Kempton, MJ, Stahl, D, de Pablo, GS, Nelson, B, Pantelis, C, Riecher-Rössler, A, Bressan, R, Barrantes-Vidal, N, Krebs, MO, Nordentoft, M, Ruhrmann, S, Sachs, G, Rutten, BPF, van Os, J, de Haan, L, van der Gaag, M, Valmaggia, LR, McGuire, P, Dominguez Martinez, T, Racioppi , A, Kwapil, T, Monsonet Bardaji, M, Hinojosa Marqués, L, Kazes, M, Daban, C, Bourgin, J, Jantac, C, Krebs, MO, Nordholm, D, Randers, L, Krakauer, K, Glenthøj, LB, Glenthøj, B, Nordentoft, M, Ruhrmann, S, Gebhard, D, Arnhold, J, Klosterkötter, J, Sachs, G, Lasser, I, Winklbaur, B, Delespaul, P & Rutten, BPF & Van Os, J 2020, 'Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis', Psychological Medicine. https://doi.org/10.1017/S0033291720003396

TY - JOUR

T1 - Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis

AU - Catalan, Ana

AU - Tognin, Stefania

AU - Kempton, Matthew J.

AU - Stahl, Daniel

AU - de Pablo, Gonzalo Salazar

AU - Nelson, Barnaby

AU - Pantelis, Christos

AU - Riecher-Rössler, Anita

AU - Bressan, Rodrigo

AU - Barrantes-Vidal, Neus

AU - Krebs, Marie Odile

AU - Nordentoft, Merete

AU - Ruhrmann, Stephan

AU - Sachs, Gabriele

AU - Rutten, Bart P.F.

AU - van Os, Jim

AU - de Haan, Lieuwe

AU - van der Gaag, Mark

AU - Valmaggia, Lucia R.

AU - McGuire, Philip

AU - Dominguez Martinez, Tecelli

AU - Racioppi , Anna

AU - Kwapil, Thomas

AU - Monsonet Bardaji, Manel

AU - Hinojosa Marqués, Lídia

AU - Kazes, M

AU - Daban, C

AU - Bourgin, J

AU - Jantac, Célia

AU - Krebs, Marie Odile

AU - Nordholm, Dorte

AU - Randers, Lasse

AU - Krakauer, Kristine

AU - Glenthøj, Louise Birkedal

AU - Glenthøj, Birte

AU - Nordentoft, Merete

AU - Ruhrmann, Stephan

AU - Gebhard, Dominika

AU - Arnhold, Julia

AU - Klosterkötter, Joachim

AU - Sachs, G

AU - Lasser, I

AU - Winklbaur, B

AU - Delespaul, Philippe

AU - Rutten, Bart P.F.

AU - Van Os, J.

N1 - Publisher Copyright: © The Author(s), 2020. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/10

Y1 - 2020/10

N2 - Background. Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods. In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. Results. There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; χ2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ.

AB - Background. Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods. In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. Results. There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; χ2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ.

KW - Functioning

KW - Psychosis

KW - Transition to psychosis

KW - Ultra high-risk

UR - https://www.scopus.com/pages/publications/85092600075

U2 - 10.1017/S0033291720003396

DO - 10.1017/S0033291720003396

M3 - Artículo

C2 - 33019957

AN - SCOPUS:85092600075

SN - 0033-2917

JO - Psychological Medicine

JF - Psychological Medicine

ER -

Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis

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Trayectorias de riesgo y resiliencia a la psicosis: estudio integrador de las interacciones gen-persona-ambiente en el fenotipo extenso de la psicosis

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