Regional serotonin effect caused by tetanus toxin intoxication in rat central nervous system

J. Aguilera, F. Gonzalez Sastre

Producció científica: Contribució a revistaArticleRecercaAvaluat per experts

Resum

The effect of tetanus toxin on the brain monoamine systems was examined by evaluating the level of norepinephrine, dopamine and serotonin in the whole brain and in different regions of the rat central nervous system (CNS). Tetanus toxin caused an increase of the rat serotonin CNS levels but no changes in the levels of catecholamines were observed. The study of the regional distribution shows that the highest increase is found in the spinal cord (70%), Lippocampus (83%), striatum (59%) and hypothalamus (70%). It appears that the size of the increment is related to the amount of serotonin innervation in each particular region. In other areas it is less pronounced (mid-brain, thalamus and cortex) or not detected (cerebellum and pons-medulla).
Idioma originalAnglès
Pàgines (de-a)91-94
RevistaBiogenic Amines
Volum6
Número1
Estat de la publicacióPublicada - 1 de gen. 1989

Fingerprint

Navegar pels temes de recerca de 'Regional serotonin effect caused by tetanus toxin intoxication in rat central nervous system'. Junts formen un fingerprint únic.

Com citar-ho