Protein polymorphism is negatively correlated with conservation of intronic sequences and complexity of expression patterns in Drosophila melanogaster

Natalia Petit*, Sònia Casillas, Alfredo Ruiz, Antonio Barbadilla

*Autor corresponent d’aquest treball

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Resum

We report a significant negative correlation between nonsynonymous polymorphism and intron length in Drosophila melanogaster. This correlation is similar to that between protein divergence and intron length previously reported in Drosophila. We show that the relationship can be explained by the content of conserved noncoding sequences (CNS) within introns. In addition, genes with a high regulatory complexity and many genetic interactions also exhibit larger amounts of CNS within their introns and lower values of nonsynonymous polymorphism. The present study provides relevant evidence on the importance of intron content and expression patterns on the levels of coding polymorphism.

Idioma originalEnglish
Pàgines (de-a)511-518
Nombre de pàgines8
RevistaJournal of Molecular Evolution
Volum64
Número5
DOIs
Estat de la publicacióPublicada - de maig 2007

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