TY - JOUR
T1 - Prospective evaluation of latent tuberculosis with interferon-γ release assays in drug and alcohol abusers
AU - Rivas, I.
AU - Latorre, I.
AU - Sanvisens, A.
AU - Domínguez, J.
AU - Tor, J.
AU - Prat, C.
AU - Rey-Joly, C.
AU - Muga, R.
PY - 2009/9/14
Y1 - 2009/9/14
N2 - In vitro tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-γ techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39.8 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon- γ assays were positive in 34% of patients with an agreement of 83% (κ = 0.63). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon- γ assays was 85% (κ = 0.62) and 83% (κ=0.57), respectively. Almost 50% of patients with history of TB had a positive in vitro test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new in vitro tests that otherwise may continue to be positive long after developing TB disease. © 2009 Cambridge University Press.
AB - In vitro tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-γ techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39.8 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon- γ assays were positive in 34% of patients with an agreement of 83% (κ = 0.63). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon- γ assays was 85% (κ = 0.62) and 83% (κ=0.57), respectively. Almost 50% of patients with history of TB had a positive in vitro test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new in vitro tests that otherwise may continue to be positive long after developing TB disease. © 2009 Cambridge University Press.
KW - Diagnosis of infection
KW - Drug abuse
KW - Interferon-γ
KW - Tuberculosis
UR - https://www.scopus.com/pages/publications/69949120168
U2 - 10.1017/S0950268809002131
DO - 10.1017/S0950268809002131
M3 - Article
SN - 0950-2688
VL - 137
SP - 1342
EP - 1347
JO - Epidemiology and Infection
JF - Epidemiology and Infection
IS - 9
ER -
