Propafenone kinetics in the horse. Comparative analysis of compartmental and noncompartmental models

Anna Puigdemont, Josep Lluis Riu, Raimon Guitart, Margarita Arboix

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    Resum

    The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models. © 1990.
    Idioma originalEnglish
    Pàgines (de-a)79-85
    RevistaJournal of Pharmacological Methods
    Volum23
    Número2
    DOIs
    Estat de la publicacióPublicada - 1 de gen. 1990

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