Progressive Painless Swelling of Glans Penis: Uncommon Clinical Manifestation of Systemic Non-Hodgkin's Lymphoma

Malignant lymphomatous involvement of the glans penis is a rare phenomenon that can be observed in either primary or secondary cutaneous lymphoma. Multiple papules, solitary nodules of variable size, ulcers, or painless masses have rarely been reported as specific and early manifestations of systemic lymphoma. Other unusual manifestations include priapism (manifested as a painless persistent erection with a flaccid glans penis) and progressive diffuse penile swelling. We report the case of a 74-year-old man presenting with progressive painless induration and swelling of the glans penis associated with mild preputial edema as the initial manifestation of systemic non-Hodgkin's lymphoma. © 2009 Elsevier Inc. All rights reserved.