Prevalence of Eight-membered hydrogen-bonded rings in some bis(cyclobutane) β-dipeptides including residues with trans stereochemistry

Elisabeth Torres, Esther Gorrea, Eric Da Silva, Pau Nolis, Vicenç Branchadell, Rosa M. Ortuño

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Resum

Three new bis(cyclobutane) β-dipeptides have been synthesized from appropriate derivatives of cis- and trans-2-aminocyclobutane-1-carboxylic acid, respectively. The predominance of eight-membered hydrogen-bonded rings has been manifested for (trans,trans)- and (trans,cis)-β- dipeptides while the formation of six-membered rings is preferred for the (cis,trans)- β-dipeptide similarly to the previously described (cis,cis)-diastereomer. © 2009 American Chemical Society.
Idioma originalAnglès
Pàgines (de-a)2301-2304
RevistaOrganic Letters
Volum11
Número11
DOIs
Estat de la publicacióPublicada - 4 de juny 2009

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