Prevalence of bronchiectasis in asthma according to oral steroid requirement: Influence of immunoglobulin levels

Manel Luján, Xavier Gallardo, María José Amengual, Montserrat Bosque, Rosa M. Mirapeix, Christian Domingo

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

30 Cites (Scopus)


Purpose. To establish the prevalence of bronchiectasis in asthma in relation to patients' oral corticosteroid requirements and to explore whether the increased risk is due to blood immunoglobulin (Ig) concentration. Methods. Case-control cross-sectional study, including 100 sex- and age-matched patients, 50 with non-steroid-dependent asthma (NSDA) and 50 with steroid-dependent asthma (SDA). Study protocol: (a) measurement of Ig and gG subclass concentration; (b) forced spirometry; and (c) high-resolution thoracic computed tomography. When bronchiectasis was detected, a specific etiological protocol was applied to establish its etiology. Results. The overall prevalence of bronchiectasis was 12/50 in the SDA group and 6/50 in the NSDA group (p=ns). The etiology was documented in six patients (four NSDA and two SDA). After excluding these patients, the prevalence of bronchiectasis was 20% (10/50) in the SDA group and 2/50 (4%) in the NSDA group (P<0.05). Patients with asthma-associated bronchiectasis presented lower FEV1 values than patients without bronchiectasis, but the levels of Ig and subclasses of IgG did not present differences. Conclusions. Steroid-dependent asthma seems to be associated with a greater risk of developing bronchiectasis than non-steroid-dependent asthma. This is probably due to the disease itself rather than to other influencing factors such as immunoglobulin levels. © 2013 Manel Luján et al.
Idioma originalEnglish
Número d’article109219
RevistaBioMed Research International
Estat de la publicacióPublicada - 16 de des. 2013


Navegar pels temes de recerca de 'Prevalence of bronchiectasis in asthma according to oral steroid requirement: Influence of immunoglobulin levels'. Junts formen un fingerprint únic.

Com citar-ho