Predictive value of ankle-brachial index and PAI-1 in symptomatic intracranial atherosclerotic disease recurrence

A. Massot; D. Giralt; A. Penalba; T. Garcia-Berrocoso; M. Navarro-Sobrino; J. F. Arenillas; M. Ribó; C. A. Molina; J. Alvarez-Sabín; J. Montaner; P. Delgado

doi:10.1016/j.atherosclerosis.2013.12.034

Predictive value of ankle-brachial index and PAI-1 in symptomatic intracranial atherosclerotic disease recurrence

A. Massot, D. Giralt, A. Penalba, T. Garcia-Berrocoso, M. Navarro-Sobrino, J. F. Arenillas, M. Ribó, C. A. Molina, J. Alvarez-Sabín, J. Montaner, P. Delgado

Departament de Medicina

Producció científica: Contribució a una revista › Article › Recerca › Avaluat per experts

6 Cites (Scopus)

Resum

Background and purpose: We prospectively examine the single and combined predictive value of biological and clinical markers in recurrent strokes related to intracranial atherosclerotic disease (ICAD). Methods: In 73 ICAD first-ever stroke patients, ankle-brachial index (ABI) was assessed three months after TIA or stroke together with CRP, Lp-PLA2, ICAM-1, E-selectin and PAI-1 measurements. Appearance of new TIA/stroke was assessed every 6 months. Results: After a median follow-up of 22.4 months, 13 patients (17.8%) suffered a new stroke or TIA. Risk of new cerebrovascular events (CVEs) was associated with lowered ABI (p=0.011), baseline PAI-1. 22.52. ng/ml (<0.001), E-selectin. 24.75. ng/ml (p=0.008) and ICAM-1. 205. ng/ml (p=0.029). The combination of PAI-1 with ABI or ESRS reclassified 55.4% (p<. 0.005) and 48.3% (p<. 0.05) of patients between low, high and very high-risk categories. Conclusions: This tentative study shows that ABI and PAI-1 are associated with the risk of new CVEs in symptomatic ICAD patients, and their combination might improve identification of patients at higher risk. © 2014 Elsevier Ireland Ltd.

Idioma original	English
Pàgines (de-a)	186-189
Revista	Atherosclerosis
Volum	233
Número	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2013.12.034
Estat de la publicació	Publicada - 1 de març 2014

Accés al document

10.1016/j.atherosclerosis.2013.12.034

Com citar-ho

Massot, A., Giralt, D., Penalba, A., Garcia-Berrocoso, T., Navarro-Sobrino, M., Arenillas, J. F., Ribó, M., Molina, C. A., Alvarez-Sabín, J., Montaner, J., & Delgado, P. (2014). Predictive value of ankle-brachial index and PAI-1 in symptomatic intracranial atherosclerotic disease recurrence. Atherosclerosis, 233(1), 186-189. https://doi.org/10.1016/j.atherosclerosis.2013.12.034

@article{470da2825e324eb596d52694f1992c1f,

title = "Predictive value of ankle-brachial index and PAI-1 in symptomatic intracranial atherosclerotic disease recurrence",

abstract = "Background and purpose: We prospectively examine the single and combined predictive value of biological and clinical markers in recurrent strokes related to intracranial atherosclerotic disease (ICAD). Methods: In 73 ICAD first-ever stroke patients, ankle-brachial index (ABI) was assessed three months after TIA or stroke together with CRP, Lp-PLA2, ICAM-1, E-selectin and PAI-1 measurements. Appearance of new TIA/stroke was assessed every 6 months. Results: After a median follow-up of 22.4 months, 13 patients (17.8%) suffered a new stroke or TIA. Risk of new cerebrovascular events (CVEs) was associated with lowered ABI (p=0.011), baseline PAI-1. 22.52. ng/ml (<0.001), E-selectin. 24.75. ng/ml (p=0.008) and ICAM-1. 205. ng/ml (p=0.029). The combination of PAI-1 with ABI or ESRS reclassified 55.4% (p<. 0.005) and 48.3% (p<. 0.05) of patients between low, high and very high-risk categories. Conclusions: This tentative study shows that ABI and PAI-1 are associated with the risk of new CVEs in symptomatic ICAD patients, and their combination might improve identification of patients at higher risk. {\textcopyright} 2014 Elsevier Ireland Ltd.",

keywords = "Ankle-brachial index, Biomarkers, Intracranial atherosclerotic disease, Intracranial stenosis, PAI-1",

author = "A. Massot and D. Giralt and A. Penalba and T. Garcia-Berrocoso and M. Navarro-Sobrino and Arenillas, {J. F.} and M. Rib{\'o} and Molina, {C. A.} and J. Alvarez-Sab{\'i}n and J. Montaner and P. Delgado",

year = "2014",

month = mar,

day = "1",

doi = "10.1016/j.atherosclerosis.2013.12.034",

language = "English",

volume = "233",

pages = "186--189",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Massot, A, Giralt, D, Penalba, A, Garcia-Berrocoso, T, Navarro-Sobrino, M, Arenillas, JF, Ribó, M, Molina, CA, Alvarez-Sabín, J, Montaner, J & Delgado, P 2014, 'Predictive value of ankle-brachial index and PAI-1 in symptomatic intracranial atherosclerotic disease recurrence', Atherosclerosis, vol. 233, núm. 1, pàg. 186-189. https://doi.org/10.1016/j.atherosclerosis.2013.12.034

TY - JOUR

T1 - Predictive value of ankle-brachial index and PAI-1 in symptomatic intracranial atherosclerotic disease recurrence

AU - Massot, A.

AU - Giralt, D.

AU - Penalba, A.

AU - Garcia-Berrocoso, T.

AU - Navarro-Sobrino, M.

AU - Arenillas, J. F.

AU - Ribó, M.

AU - Molina, C. A.

AU - Alvarez-Sabín, J.

AU - Montaner, J.

AU - Delgado, P.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Background and purpose: We prospectively examine the single and combined predictive value of biological and clinical markers in recurrent strokes related to intracranial atherosclerotic disease (ICAD). Methods: In 73 ICAD first-ever stroke patients, ankle-brachial index (ABI) was assessed three months after TIA or stroke together with CRP, Lp-PLA2, ICAM-1, E-selectin and PAI-1 measurements. Appearance of new TIA/stroke was assessed every 6 months. Results: After a median follow-up of 22.4 months, 13 patients (17.8%) suffered a new stroke or TIA. Risk of new cerebrovascular events (CVEs) was associated with lowered ABI (p=0.011), baseline PAI-1. 22.52. ng/ml (<0.001), E-selectin. 24.75. ng/ml (p=0.008) and ICAM-1. 205. ng/ml (p=0.029). The combination of PAI-1 with ABI or ESRS reclassified 55.4% (p<. 0.005) and 48.3% (p<. 0.05) of patients between low, high and very high-risk categories. Conclusions: This tentative study shows that ABI and PAI-1 are associated with the risk of new CVEs in symptomatic ICAD patients, and their combination might improve identification of patients at higher risk. © 2014 Elsevier Ireland Ltd.

AB - Background and purpose: We prospectively examine the single and combined predictive value of biological and clinical markers in recurrent strokes related to intracranial atherosclerotic disease (ICAD). Methods: In 73 ICAD first-ever stroke patients, ankle-brachial index (ABI) was assessed three months after TIA or stroke together with CRP, Lp-PLA2, ICAM-1, E-selectin and PAI-1 measurements. Appearance of new TIA/stroke was assessed every 6 months. Results: After a median follow-up of 22.4 months, 13 patients (17.8%) suffered a new stroke or TIA. Risk of new cerebrovascular events (CVEs) was associated with lowered ABI (p=0.011), baseline PAI-1. 22.52. ng/ml (<0.001), E-selectin. 24.75. ng/ml (p=0.008) and ICAM-1. 205. ng/ml (p=0.029). The combination of PAI-1 with ABI or ESRS reclassified 55.4% (p<. 0.005) and 48.3% (p<. 0.05) of patients between low, high and very high-risk categories. Conclusions: This tentative study shows that ABI and PAI-1 are associated with the risk of new CVEs in symptomatic ICAD patients, and their combination might improve identification of patients at higher risk. © 2014 Elsevier Ireland Ltd.

KW - Ankle-brachial index

KW - Biomarkers

KW - Intracranial atherosclerotic disease

KW - Intracranial stenosis

KW - PAI-1

U2 - 10.1016/j.atherosclerosis.2013.12.034

DO - 10.1016/j.atherosclerosis.2013.12.034

M3 - Article

SN - 0021-9150

VL - 233

SP - 186

EP - 189

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

Predictive value of ankle-brachial index and PAI-1 in symptomatic intracranial atherosclerotic disease recurrence

Resum

Accés al document

Fingerprint

Com citar-ho