Postcibal secretory and symptomatic responses to increased intragastric pressure

E. SAPERAS, F. AZPIROZ, M. CUCALA, R. RODRIGUEZ, J. ‐R MALAGELADA

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

4 Cites (Scopus)

Resum

Abstract The mechanical and secretory factors in the stomach that may be implicated in the production of symptoms are still poorly understood. To determine whether symptoms in response to postcibal gastric distention are associated with increased acid secretion, the relationship between symptoms, acid secretion and intragastric pressure in healthy subjects was investigated. Perception (by a 0–6 score questionnaire) and the gastric secretory response to a glucose test meal (by intragastric titration) was quantified either at low (2 mmHg) or at high (8 mmHg) intragastric pressure levels, maintained by feedback regulation of the air volume within a gastric bag using an electronic barostat. Low intragastric pressure produced a small gastric expansion (87 ± 26 ml; mean ± SE) that was largely unperceived (score 0.7 ± 0.5). High intragastric pressure did not increase acid secretion (15 ± 3 mEq h‐1 vs 16 ± 3 mEq h‐1 at low pressure), but produced symptomatic perception (score 2.5 ± 0.7) related to a marked gastric expansion (521 ± 92 ml; P < 0.05 vs low pressure for both). It was concluded that postcibal gastric hypertension induces symptoms without affecting the gastric acid secretory response to the meal. Copyright © 1994, Wiley Blackwell. All rights reserved
Idioma originalEnglish
Pàgines (de-a)295-301
RevistaNeurogastroenterology and Motility
Volum6
Número4
DOIs
Estat de la publicacióPublicada - 1 de gen. 1994

Fingerprint

Navegar pels temes de recerca de 'Postcibal secretory and symptomatic responses to increased intragastric pressure'. Junts formen un fingerprint únic.

Com citar-ho