Resum
Copyright © 2019 American Society for Microbiology. All Rights Reserved. A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations suggested that patients with higher TBWs had less-extensive MIC coverage. Dosage escalation may be warranted in patients with high TBWs to ensure optimal drug exposures for treatment of Candida albicans and Candida glabrata infections.
Idioma original | Anglès |
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Número d’article | e00378-19 |
Revista | Antimicrobial Agents and Chemotherapy |
Volum | 63 |
Número | 7 |
DOIs | |
Estat de la publicació | Publicada - de jul. 2019 |