@article{170a64949b2849aa8447283387242f8c,
title = "Plasma induced reactive oxygen species-dependent cytotoxicity in glioblastoma 3D tumourspheres",
abstract = "The aim of this study was to determine the effects of a pin-to-plate cold atmospheric plasma (CAP) on U-251 MG three-dimensional (3D) glioblastoma spheroids under different conditions. 3D tumorspheres showed higher resistance to the CAP treatment compared to 2D monolayer cells. A single CAP treatment was able to induce cytotoxicity, while multiple CAP treatments augmented this effect. CAP was also able to induce cytotoxicity throughout the tumoursphere, and we identified that reactive oxygen species (ROS) plays a major role, while H2O2 plays a partial role in CAP-induced cytotoxicity in tumourspheres. We conclude that ROS-dependent cytotoxicity is induced uniformly throughout glioblastoma and epidermoid tumourspheres by direct CAP treatment.",
keywords = "3D tumourspheres, cold atmospheric plasma, cytotoxicity, epidermoid, glioblastoma, reactive oxygen and nitrogen species, ROS dependent",
author = "Janith Wanigasekara and Carlos Barcia and Cullen, {Patrick J.} and Brijesh Tiwari and Curtin, {James F.}",
note = "Funding Information: This study was supported by Science Foundation Ireland (SFI) under Grant Number 17/CDA/4653 and funded through Teagasc Walsh Fellowship. The authors also thank TU Dublin, ESHI, and FOCAS Research Institutes for the use of facilities and support of technical staff. Open access funding enabled and organized by IReL. Funding Information: This study was supported by Science Foundation Ireland (SFI) under Grant Number 17/CDA/4653 and funded through Teagasc Walsh Fellowship. The authors also thank TU Dublin, ESHI, and FOCAS Research Institutes for the use of facilities and support of technical staff. Publisher Copyright: {\textcopyright} 2022 The Authors. Plasma Processes and Polymers published by Wiley-VCH GmbH.",
year = "2022",
month = apr,
doi = "10.1002/ppap.202100157",
language = "English",
volume = "19",
journal = "Plasma Processes and Polymers",
issn = "1612-8850",
publisher = "Wiley-VCH Verlag",
number = "4",
}