TY - JOUR
T1 - Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder.
AU - Galván, ST
AU - Flores-López, M
AU - Romero-Sanchiz, P
AU - Requena-Ocaña, N
AU - Porras-Perales, O
AU - Nogueira-Arjona, R
AU - Mayoral, F
AU - Araos, P
AU - Serrano, A
AU - Muga, R
AU - Pavón, FJ
AU - García-Marchena, N
AU - Rodríguez, de Fonseca F
N1 - Funding
The present study has been supported by the following programs and research projects: Subprograma Redes Temáticas RETICS (Red de Trastornos Adictivos RD16/0017/001 and RD16/0017/0003) funded by Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad and the European Regional Development Funds/European Social Fund (ERDF/ESF); Proyectos de Investigación en Salud (PI17/02026, PI19/00886, PI19/01577, PI20/0883) funded by ISCIII and ERDF/ESF; Proyectos de Investigación en Drogodependencias (PND2017/043, PND2018/033, PND2018/044, PND2019/040 and PNSD2020/024) funded by Delegación del Gobierno para el Plan Nacional sobre Drogas, Ministerio de Sanidad and ERDF/ESF; Proyecto de Investigación en Salud (PI-0140–2018) funded by Consejería de Salud y Familias, Junta de Andalucía and ERDF/ESF. NGM holds a “Sara Borrell” research contract (CD19/00019) funded by ISCIII and ERDF/ESF. FJP and AS hold a “Miguel Servet II” research contract (CPII19/00022 and CPII19/00031 respectively) funded by ISCIII and ERDF/ESF.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = − 0.233, p
AB - Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = − 0.233, p
UR - https://www.scopus.com/pages/publications/85109124784
U2 - 10.1038/s41598-021-93075-1
DO - 10.1038/s41598-021-93075-1
M3 - Article
VL - 11
JO - Sci Reports
JF - Sci Reports
IS - 1
M1 - 13629
ER -
