Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

L. Calpe-Berdiel; J. C. Escolà-Gil; Noemi Rotllan; F. Blanco-Vaca

doi:10.1016/j.metabol.2008.06.002

Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

L. Calpe-Berdiel, J. C. Escolà-Gil, Noemi Rotllan, F. Blanco-Vaca

Departament de Bioquímica i de Biologia Molecular

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Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used. © 2008 Elsevier Inc. All rights reserved.

Idioma original	Anglès
Pàgines (de-a)	1497-1501
Revista	Metabolism: Clinical and Experimental
Volum	57
Número	11
DOIs	https://doi.org/10.1016/j.metabol.2008.06.002
Estat de la publicació	Publicada - 1 de nov. 2008

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10.1016/j.metabol.2008.06.002

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title = "Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice",

abstract = "Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used. {\textcopyright} 2008 Elsevier Inc. All rights reserved.",

author = "L. Calpe-Berdiel and Escol{\`a}-Gil, {J. C.} and Noemi Rotllan and F. Blanco-Vaca",

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Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice. / Calpe-Berdiel, L.; Escolà-Gil, J. C.; Rotllan, Noemi et al.
In: Metabolism: Clinical and Experimental, Vol. 57, Núm. 11, 01.11.2008, pàg. 1497-1501.

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

TY - JOUR

T1 - Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

AU - Calpe-Berdiel, L.

AU - Escolà-Gil, J. C.

AU - Rotllan, Noemi

AU - Blanco-Vaca, F.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used. © 2008 Elsevier Inc. All rights reserved.

AB - Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used. © 2008 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.metabol.2008.06.002

DO - 10.1016/j.metabol.2008.06.002

M3 - Article

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VL - 57

SP - 1497

EP - 1501

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - 11

ER -

Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

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