TY - JOUR
T1 - Partial lack of BCL2 in follicular lymphoma: An unusual immunohistochemical staining pattern explained by ongoing BCL2 mutation
AU - van den Brand, Michiel
AU - Garcia-Garcia, Mar
AU - Mathijssen, Janneke J.M.
AU - Colomo, Lluis
AU - Groenen, Patricia J.T.A.
AU - Serrano, Sergio
AU - van Krieken, J. Han J.M.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - © 2015 Elsevier GmbH. Follicular lymphomas are characterized by overexpression of BCL2 which, in the large majority of cases, is due to a t(14;18) translocation which juxtaposes the BCL2 locus to the immunoglobulin heavy chain locus (IGH). Here, we report partial absence of BCL2 immunohistochemical staining in a case of FL, due to a mutation in the part of BCL2 that encodes the epitope for the most frequently used antibody against BCL2. This finding shows that mutations in BCL2 occur in an ongoing process in follicular which can give rise to unusual immunohistochemical staining patterns.
AB - © 2015 Elsevier GmbH. Follicular lymphomas are characterized by overexpression of BCL2 which, in the large majority of cases, is due to a t(14;18) translocation which juxtaposes the BCL2 locus to the immunoglobulin heavy chain locus (IGH). Here, we report partial absence of BCL2 immunohistochemical staining in a case of FL, due to a mutation in the part of BCL2 that encodes the epitope for the most frequently used antibody against BCL2. This finding shows that mutations in BCL2 occur in an ongoing process in follicular which can give rise to unusual immunohistochemical staining patterns.
KW - BCL2
KW - Follicular lymphoma
KW - Immunohistochemistry
U2 - 10.1016/j.prp.2015.12.001
DO - 10.1016/j.prp.2015.12.001
M3 - Article
SN - 0344-0338
VL - 212
SP - 148
EP - 150
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 2
ER -