p53 Controls Meiotic Prophase Progression and Crossover Formation

Marina Marcet-Ortega, Andros Maldonado-Linares, Maria López-Panadés, Ignasi Roig*

*Autor corresponent d’aquest treball

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4 Cites (Scopus)

Resum

Meiosis initiates with the formation of double strand breaks (DSBs) throughout the genome. To avoid genomic instability, these DSBs need to be correctly repaired by homologous recombination. Surveillance mechanisms involving the DNA damage response (DDR) pathway ATM-CHK2-p53 can detect the persistence of unrepaired DBSs and activate the recombination-dependent arrest at the pachytene stage. However, a complete understanding of p53 functions under normal physiological conditions remains lacking. Here, we report a detailed analysis of the p53 role during meiotic prophase in mice spermatocytes. We show that the absence of p53 regulates prophase progression by slowing down the pachytene stage when the recombination-dependent arrest occurs. Furthermore, our results show that p53 is necessary for proper crossover (CO) formation and localization. Our study contributes to a deeper understanding of p53 roles during the meiotic prophase.

Idioma originalEnglish
Número d’article9818
RevistaInternational journal of molecular sciences
Volum23
Número17
DOIs
Estat de la publicacióPublicada - 29 d’ag. 2022

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