P21(WAF1/Cip1) expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx

A Nadal, P Jares, M Cazorla, PL Fernandez, G. Sanjuan, L Hernandez, M Pinyol, M Aldea, C Mallofre, J Muntane, J Traserra, E Campo, A Cardesa

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Resum

p21(WAF1/Cip1) is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines stems to be induced by wild-type, but not mutant, p53, p21(WAF1/Cip1) expression has been studied at both mRNA and protein levels in a series of 49 normal mucosae and squamous cell carcinomas of the larynx, A significant association was found between mRNA and protein expression in tumours (P

Idioma originalEnglish
Pàgines (de-a)156-163
Nombre de pàgines8
RevistaJ. Pathol.
Volum183
Número2
Estat de la publicacióPublicada - d’oct. 1997

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