Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries

Sara Lodi; Julia Del Amo; Santiago Moreno; Heiner C. Bucher; Hansjakob Furrer; Roger Logan; Jonathan Sterne; Santiago Pérez-Hoyos; Inma Jarrín; Andrew Phillips; Ashley Olson; Ard Van Sighem; Peter Reiss; Caroline Sabin; Sophie Jose; Amy Justice; Joseph Goulet; José M. Miró; Elena Ferrer; Laurence Meyer; Rémonie Seng; Georgia Vourli; Anastasia Antoniadou; Francois Dabis; Mari Anne Vandenhede; Dominique Costagliola; Sophie Abgrall; Miguel A. Hernán; Miguel Hernan; L. Bansi; T. Hill; C. Sabin; D. Dunn; K. Porter; A. Glabay; C. Orkin; R. Thomas; K. Jones; M. Fisher; N. Perry; A. Pullin; D. Churchill; B. Gazzard; M. Nelson; D. Asboe; S. Bulbeck; S. Mandalia; J. Clarke; V. Delpech; J. Anderson; S. Munshi; F. Post; P. Easterbrook; Y. Khan; P. Patel; F. Karim; S. Duffell; R. Gilson; S. L. Man; I. Williams; M. Gompels; D. Dooley; A. Schwenk; J. Ainsworth; M. Johnson; M. Youle; F. Lampe; C. Smith; H. Grabowska; C. Chaloner; D. Ismajani Puradiredja; L. Bansi; T. Hill; A. Phillips; C. Sabin; J. Walsh; J. Weber; C. Kemble; N. Mackie; A. Winston; C. Leen; A. Wilson; D. O. Bezemer; L. A.J. Gras; A. M. Kesselring; A. I. Van Sighem; S. Zaheri; G. Van Twillert; W. Kortmann; J. Branger; J. M. Prins; T. W. Kuijpers; H. J. Scherpbier; J. T.M. Van Der Meer; F. W.M.N. Wit; M. H. Godfried; P. Reiss; T. Van Der Poll; F. J.B. Nellen; J. M.A. Lange

doi:10.1097/QAD.0000000000000456

Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries

Sara Lodi, Julia Del Amo, Santiago Moreno, Heiner C. Bucher, Hansjakob Furrer, Roger Logan, Jonathan Sterne, Santiago Pérez-Hoyos, Inma Jarrín, Andrew Phillips, Ashley Olson, Ard Van Sighem, Peter Reiss, Caroline Sabin, Sophie Jose, Amy Justice, Joseph Goulet, José M. Miró, Elena Ferrer, Laurence MeyerRémonie Seng, Georgia Vourli, Anastasia Antoniadou, Francois Dabis, Mari Anne Vandenhede, Dominique Costagliola, Sophie Abgrall, Miguel A. Hernán, Miguel Hernan, L. Bansi, T. Hill, C. Sabin, D. Dunn, K. Porter, A. Glabay, C. Orkin, R. Thomas, K. Jones, M. Fisher, N. Perry, A. Pullin, D. Churchill, B. Gazzard, M. Nelson, D. Asboe, S. Bulbeck, S. Mandalia, J. Clarke, V. Delpech, J. Anderson, S. Munshi, F. Post, P. Easterbrook, Y. Khan, P. Patel, F. Karim, S. Duffell, R. Gilson, S. L. Man, I. Williams, M. Gompels, D. Dooley, A. Schwenk, J. Ainsworth, M. Johnson, M. Youle, F. Lampe, C. Smith, H. Grabowska, C. Chaloner, D. Ismajani Puradiredja, L. Bansi, T. Hill, A. Phillips, C. Sabin, J. Walsh, J. Weber, C. Kemble, N. Mackie, A. Winston, C. Leen, A. Wilson, D. O. Bezemer, L. A.J. Gras, A. M. Kesselring, A. I. Van Sighem, S. Zaheri, G. Van Twillert, W. Kortmann, J. Branger, J. M. Prins, T. W. Kuijpers, H. J. Scherpbier, J. T.M. Van Der Meer, F. W.M.N. Wit, M. H. Godfried, P. Reiss, T. Van Der Poll, F. J.B. Nellen, J. M.A. Lange

Departament de Pediatria, d’Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

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© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.

Idioma original	Anglès
Pàgines (de-a)	2461-2473
Revista	AIDS
Volum	28
Número	16
DOIs	https://doi.org/10.1097/QAD.0000000000000456
Estat de la publicació	Publicada - 1 de gen. 2014

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Lodi, S., Del Amo, J., Moreno, S., Bucher, H. C., Furrer, H., Logan, R., Sterne, J., Pérez-Hoyos, S., Jarrín, I., Phillips, A., Olson, A., Van Sighem, A., Reiss, P., Sabin, C., Jose, S., Justice, A., Goulet, J., Miró, J. M., Ferrer, E., ... Lange, J. M. A. (2014). Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries. AIDS, 28(16), 2461-2473. https://doi.org/10.1097/QAD.0000000000000456

@article{8f15a51eb3c44a6092ebd83efb22d55f,

title = "Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries",

abstract = "{\textcopyright} 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.",

keywords = "HIV, Immune reconstitution inflammatory syndrome, Incidence, Inverse probability weighting, Unmasking",

author = "Sara Lodi and {Del Amo}, Julia and Santiago Moreno and Bucher, {Heiner C.} and Hansjakob Furrer and Roger Logan and Jonathan Sterne and Santiago P{\'e}rez-Hoyos and Inma Jarr{\'i}n and Andrew Phillips and Ashley Olson and {Van Sighem}, Ard and Peter Reiss and Caroline Sabin and Sophie Jose and Amy Justice and Joseph Goulet and Mir{\'o}, {Jos{\'e} M.} and Elena Ferrer and Laurence Meyer and R{\'e}monie Seng and Georgia Vourli and Anastasia Antoniadou and Francois Dabis and Vandenhede, {Mari Anne} and Dominique Costagliola and Sophie Abgrall and Hern{\'a}n, {Miguel A.} and Miguel Hernan and L. Bansi and T. Hill and C. Sabin and D. Dunn and K. Porter and A. Glabay and C. Orkin and R. Thomas and K. Jones and M. Fisher and N. Perry and A. Pullin and D. Churchill and B. Gazzard and M. Nelson and D. Asboe and S. Bulbeck and S. Mandalia and J. Clarke and V. Delpech and J. Anderson and S. Munshi and F. Post and P. Easterbrook and Y. Khan and P. Patel and F. Karim and S. Duffell and R. Gilson and Man, {S. L.} and I. Williams and M. Gompels and D. Dooley and A. Schwenk and J. Ainsworth and M. Johnson and M. Youle and F. Lampe and C. Smith and H. Grabowska and C. Chaloner and {Ismajani Puradiredja}, D. and L. Bansi and T. Hill and A. Phillips and C. Sabin and J. Walsh and J. Weber and C. Kemble and N. Mackie and A. Winston and C. Leen and A. Wilson and Bezemer, {D. O.} and Gras, {L. A.J.} and Kesselring, {A. M.} and {Van Sighem}, {A. I.} and S. Zaheri and {Van Twillert}, G. and W. Kortmann and J. Branger and Prins, {J. M.} and Kuijpers, {T. W.} and Scherpbier, {H. J.} and {Van Der Meer}, {J. T.M.} and Wit, {F. W.M.N.} and Godfried, {M. H.} and P. Reiss and {Van Der Poll}, T. and Nellen, {F. J.B.} and Lange, {J. M.A.}",

year = "2014",

month = jan,

day = "1",

doi = "10.1097/QAD.0000000000000456",

language = "English",

volume = "28",

pages = "2461--2473",

number = "16",

}

Lodi, S, Del Amo, J, Moreno, S, Bucher, HC, Furrer, H, Logan, R, Sterne, J, Pérez-Hoyos, S, Jarrín, I, Phillips, A, Olson, A, Van Sighem, A, Reiss, P, Sabin, C, Jose, S, Justice, A, Goulet, J, Miró, JM, Ferrer, E, Meyer, L, Seng, R, Vourli, G, Antoniadou, A, Dabis, F, Vandenhede, MA, Costagliola, D, Abgrall, S, Hernán, MA, Hernan, M, Bansi, L, Hill, T, Sabin, C, Dunn, D, Porter, K, Glabay, A, Orkin, C, Thomas, R, Jones, K, Fisher, M, Perry, N, Pullin, A, Churchill, D, Gazzard, B, Nelson, M, Asboe, D, Bulbeck, S, Mandalia, S, Clarke, J, Delpech, V, Anderson, J, Munshi, S, Post, F, Easterbrook, P, Khan, Y, Patel, P, Karim, F, Duffell, S, Gilson, R, Man, SL, Williams, I, Gompels, M, Dooley, D, Schwenk, A, Ainsworth, J, Johnson, M, Youle, M, Lampe, F, Smith, C, Grabowska, H, Chaloner, C, Ismajani Puradiredja, D, Bansi, L, Hill, T, Phillips, A, Sabin, C, Walsh, J, Weber, J, Kemble, C, Mackie, N, Winston, A, Leen, C, Wilson, A, Bezemer, DO, Gras, LAJ, Kesselring, AM, Van Sighem, AI, Zaheri, S, Van Twillert, G, Kortmann, W, Branger, J, Prins, JM, Kuijpers, TW, Scherpbier, HJ, Van Der Meer, JTM, Wit, FWMN, Godfried, MH, Reiss, P, Van Der Poll, T, Nellen, FJB & Lange, JMA 2014, 'Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries', AIDS, vol. 28, núm. 16, pàg. 2461-2473. https://doi.org/10.1097/QAD.0000000000000456

TY - JOUR

T1 - Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries

AU - Lodi, Sara

AU - Del Amo, Julia

AU - Moreno, Santiago

AU - Bucher, Heiner C.

AU - Furrer, Hansjakob

AU - Logan, Roger

AU - Sterne, Jonathan

AU - Pérez-Hoyos, Santiago

AU - Jarrín, Inma

AU - Phillips, Andrew

AU - Olson, Ashley

AU - Van Sighem, Ard

AU - Reiss, Peter

AU - Sabin, Caroline

AU - Jose, Sophie

AU - Justice, Amy

AU - Goulet, Joseph

AU - Miró, José M.

AU - Ferrer, Elena

AU - Meyer, Laurence

AU - Seng, Rémonie

AU - Vourli, Georgia

AU - Antoniadou, Anastasia

AU - Dabis, Francois

AU - Vandenhede, Mari Anne

AU - Costagliola, Dominique

AU - Abgrall, Sophie

AU - Hernán, Miguel A.

AU - Hernan, Miguel

AU - Bansi, L.

AU - Hill, T.

AU - Sabin, C.

AU - Dunn, D.

AU - Porter, K.

AU - Glabay, A.

AU - Orkin, C.

AU - Thomas, R.

AU - Jones, K.

AU - Fisher, M.

AU - Perry, N.

AU - Pullin, A.

AU - Churchill, D.

AU - Gazzard, B.

AU - Nelson, M.

AU - Asboe, D.

AU - Bulbeck, S.

AU - Mandalia, S.

AU - Clarke, J.

AU - Delpech, V.

AU - Anderson, J.

AU - Munshi, S.

AU - Post, F.

AU - Easterbrook, P.

AU - Khan, Y.

AU - Patel, P.

AU - Karim, F.

AU - Duffell, S.

AU - Gilson, R.

AU - Man, S. L.

AU - Williams, I.

AU - Gompels, M.

AU - Dooley, D.

AU - Schwenk, A.

AU - Ainsworth, J.

AU - Johnson, M.

AU - Youle, M.

AU - Lampe, F.

AU - Smith, C.

AU - Grabowska, H.

AU - Chaloner, C.

AU - Ismajani Puradiredja, D.

AU - Bansi, L.

AU - Hill, T.

AU - Phillips, A.

AU - Sabin, C.

AU - Walsh, J.

AU - Weber, J.

AU - Kemble, C.

AU - Mackie, N.

AU - Winston, A.

AU - Leen, C.

AU - Wilson, A.

AU - Bezemer, D. O.

AU - Gras, L. A.J.

AU - Kesselring, A. M.

AU - Van Sighem, A. I.

AU - Zaheri, S.

AU - Van Twillert, G.

AU - Kortmann, W.

AU - Branger, J.

AU - Prins, J. M.

AU - Kuijpers, T. W.

AU - Scherpbier, H. J.

AU - Van Der Meer, J. T.M.

AU - Wit, F. W.M.N.

AU - Godfried, M. H.

AU - Reiss, P.

AU - Van Der Poll, T.

AU - Nellen, F. J.B.

AU - Lange, J. M.A.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.

AB - © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.

KW - HIV

KW - Immune reconstitution inflammatory syndrome

KW - Incidence

KW - Inverse probability weighting

KW - Unmasking

U2 - 10.1097/QAD.0000000000000456

DO - 10.1097/QAD.0000000000000456

M3 - Article

SN - 0269-9370

VL - 28

SP - 2461

EP - 2473

JO - AIDS

JF - AIDS

IS - 16

ER -

Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries

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