On Biocompatibility and Stability of Transversal Intrafascicular Multichannel Electrodes—TIME

Thomas Stieglitz; Tim Boretius; Paul Čvančara; David Guiraud; Thomas Guiho; Victor Manuel Lopez-Alvarez; Xavier Navarro

doi:10.1007/978-3-319-46669-9_120

On Biocompatibility and Stability of Transversal Intrafascicular Multichannel Electrodes—TIME

Thomas Stieglitz, Tim Boretius, Paul Čvančara, David Guiraud, Thomas Guiho, Victor Manuel Lopez-Alvarez, Xavier Navarro

Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

Producció científica: Capítol de llibre › Capítol › Recerca › Avaluat per experts

4 Cites (Scopus)

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© Springer International Publishing AG 2017. Transversal intrafascicular multichannel electrodes (TIME) have been developed to interface with peripheral nerves after upper limb amputation. Intended use is the electrical stimulation of the median and ulnar nerve to deliver sensory feedback during phantom limb pain treatment and artificial hand control. Miniaturized electrode arrays were developed on polyimide substrates with thin film metallization using sputtered iridium oxide as electrode coating. Here, we report on the essential requirements including biocompatibility, mechanical and stimulation stability that have been investigated before permission was granted by the legal authorities to conduct subchronic first-in-man clinical trials. Explants have been investigated to identify possible first failure points and optimize the devices for chronic implantation.

Idioma original	Anglès
Títol de la publicació	Biosystems and Biorobotics
Pàgines	731-735
Nombre de pàgines	4
Volum	15
ISBN (electrònic)	2195-3570
DOIs	https://doi.org/10.1007/978-3-319-46669-9_120
Estat de la publicació	Publicada - 1 de gen. 2017

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author = "Thomas Stieglitz and Tim Boretius and Paul {\v C}van{\v c}ara and David Guiraud and Thomas Guiho and Lopez-Alvarez, {Victor Manuel} and Xavier Navarro",

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doi = "10.1007/978-3-319-46669-9_120",

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AU - Stieglitz, Thomas

AU - Boretius, Tim

AU - Čvančara, Paul

AU - Guiraud, David

AU - Guiho, Thomas

AU - Lopez-Alvarez, Victor Manuel

AU - Navarro, Xavier

PY - 2017/1/1

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N2 - © Springer International Publishing AG 2017. Transversal intrafascicular multichannel electrodes (TIME) have been developed to interface with peripheral nerves after upper limb amputation. Intended use is the electrical stimulation of the median and ulnar nerve to deliver sensory feedback during phantom limb pain treatment and artificial hand control. Miniaturized electrode arrays were developed on polyimide substrates with thin film metallization using sputtered iridium oxide as electrode coating. Here, we report on the essential requirements including biocompatibility, mechanical and stimulation stability that have been investigated before permission was granted by the legal authorities to conduct subchronic first-in-man clinical trials. Explants have been investigated to identify possible first failure points and optimize the devices for chronic implantation.

AB - © Springer International Publishing AG 2017. Transversal intrafascicular multichannel electrodes (TIME) have been developed to interface with peripheral nerves after upper limb amputation. Intended use is the electrical stimulation of the median and ulnar nerve to deliver sensory feedback during phantom limb pain treatment and artificial hand control. Miniaturized electrode arrays were developed on polyimide substrates with thin film metallization using sputtered iridium oxide as electrode coating. Here, we report on the essential requirements including biocompatibility, mechanical and stimulation stability that have been investigated before permission was granted by the legal authorities to conduct subchronic first-in-man clinical trials. Explants have been investigated to identify possible first failure points and optimize the devices for chronic implantation.

U2 - 10.1007/978-3-319-46669-9_120

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M3 - Chapter

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SP - 731

EP - 735

BT - Biosystems and Biorobotics

ER -

On Biocompatibility and Stability of Transversal Intrafascicular Multichannel Electrodes—TIME

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