TY - JOUR
T1 - Noninvasive diagnosis of liver fibrosis in patients with HIV infection and HCV/HBV co-infection
AU - Moreno, S.
AU - García-Samaniego, J.
AU - Moreno, A.
AU - Ortega, E.
AU - Pineda, J. A.
AU - Del Romero, J.
AU - Tural, C.
AU - Von Wichmann, M. A.
AU - Berenguer, J.
AU - Castro, Á
AU - Espacio, R.
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Summary. The measurement of fibrosis stage critically affects the identification of the progression of liver disease, the establishment of a prognosis and therapeutic decision making. Liver biopsy has been the single, most useful method to determine the degree of liver fibrosis (LF), but with recognized limitations, mainly associated with its invasiveness. In recent years, alternative noninvasive methods have been developed, including imaging methods, such as transient elastometry, and assays based on serum biomarkers. This article reviews the available studies evaluating the value of various noninvasive methods for the assessment of LF in patients with HIV-infection and HBV/HCV co-infection, and makes recommendations on how to best use and combine them in clinical practice. © 2009 Blackwell Publishing Ltd.
AB - Summary. The measurement of fibrosis stage critically affects the identification of the progression of liver disease, the establishment of a prognosis and therapeutic decision making. Liver biopsy has been the single, most useful method to determine the degree of liver fibrosis (LF), but with recognized limitations, mainly associated with its invasiveness. In recent years, alternative noninvasive methods have been developed, including imaging methods, such as transient elastometry, and assays based on serum biomarkers. This article reviews the available studies evaluating the value of various noninvasive methods for the assessment of LF in patients with HIV-infection and HBV/HCV co-infection, and makes recommendations on how to best use and combine them in clinical practice. © 2009 Blackwell Publishing Ltd.
KW - Elastometry
KW - HIV/HCV co-infection
KW - Liver biopsy
KW - Liver fibrosis
KW - Serum markers
U2 - 10.1111/j.1365-2893.2009.01088.x
DO - 10.1111/j.1365-2893.2009.01088.x
M3 - Review article
SN - 1352-0504
VL - 16
SP - 249
EP - 258
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
IS - 4
ER -
