No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis

Franca R. Guerini; Mario Clerici; Rachele Cagliani; Sunny Malhotra; Xavier Montalban; Diego Forni; Cristina Agliardi; Stefania Riva; Domenico Caputo; Daniela Galimberti; Rosanna Asselta; Chiara Fenoglio; Elio Scarpini; Giacomo P. Comi; Nereo Bresolin; Manuel Comabella; Manuela Sironi

doi:10.1016/j.jneuroim.2014.04.006

No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis

Franca R. Guerini, Mario Clerici, Rachele Cagliani, Sunny Malhotra, Xavier Montalban, Diego Forni, Cristina Agliardi, Stefania Riva, Domenico Caputo, Daniela Galimberti, Rosanna Asselta, Chiara Fenoglio, Elio Scarpini, Giacomo P. Comi, Nereo Bresolin, Manuel Comabella, Manuela Sironi^*

^*Autor corresponent d’aquest treball

Departament de Medicina

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

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Resum

IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

Idioma original	Anglès
Pàgines (de-a)	49-52
Nombre de pàgines	4
Revista	Journal of Neuroimmunology
Volum	271
Número	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2014.04.006
Estat de la publicació	Publicada - 15 de juny 2014

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10.1016/j.jneuroim.2014.04.006Llicència: C In Copyright

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Guerini, F. R., Clerici, M., Cagliani, R., Malhotra, S., Montalban, X., Forni, D., Agliardi, C., Riva, S., Caputo, D., Galimberti, D., Asselta, R., Fenoglio, C., Scarpini, E., Comi, G. P., Bresolin, N., Comabella, M., & Sironi, M. (2014). No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis. Journal of Neuroimmunology, 271(1-2), 49-52. https://doi.org/10.1016/j.jneuroim.2014.04.006

@article{ab1caa03095f4a77aad9a531f937e077,

title = "No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis",

abstract = "IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.",

keywords = "EBV infection, Genetic susceptibility, IFI16 (interferon-inducible protein 16), Multiple sclerosis",

author = "Guerini, {Franca R.} and Mario Clerici and Rachele Cagliani and Sunny Malhotra and Xavier Montalban and Diego Forni and Cristina Agliardi and Stefania Riva and Domenico Caputo and Daniela Galimberti and Rosanna Asselta and Chiara Fenoglio and Elio Scarpini and Comi, {Giacomo P.} and Nereo Bresolin and Manuel Comabella and Manuela Sironi",

year = "2014",

month = jun,

day = "15",

doi = "10.1016/j.jneuroim.2014.04.006",

language = "English",

volume = "271",

pages = "49--52",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

Guerini, FR, Clerici, M, Cagliani, R, Malhotra, S, Montalban, X, Forni, D, Agliardi, C, Riva, S, Caputo, D, Galimberti, D, Asselta, R, Fenoglio, C, Scarpini, E, Comi, GP, Bresolin, N, Comabella, M & Sironi, M 2014, 'No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis', Journal of Neuroimmunology, vol. 271, núm. 1-2, pàg. 49-52. https://doi.org/10.1016/j.jneuroim.2014.04.006

TY - JOUR

T1 - No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis

AU - Guerini, Franca R.

AU - Clerici, Mario

AU - Cagliani, Rachele

AU - Malhotra, Sunny

AU - Montalban, Xavier

AU - Forni, Diego

AU - Agliardi, Cristina

AU - Riva, Stefania

AU - Caputo, Domenico

AU - Galimberti, Daniela

AU - Asselta, Rosanna

AU - Fenoglio, Chiara

AU - Scarpini, Elio

AU - Comi, Giacomo P.

AU - Bresolin, Nereo

AU - Comabella, Manuel

AU - Sironi, Manuela

PY - 2014/6/15

Y1 - 2014/6/15

N2 - IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

AB - IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

KW - EBV infection

KW - Genetic susceptibility

KW - IFI16 (interferon-inducible protein 16)

KW - Multiple sclerosis

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U2 - 10.1016/j.jneuroim.2014.04.006

DO - 10.1016/j.jneuroim.2014.04.006

M3 - Article

C2 - 24794504

AN - SCOPUS:84900512600

SN - 0165-5728

VL - 271

SP - 49

EP - 52

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis

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